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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by LLL on August 17, 2002, at 19:43:27
I just came across a few articles on ondansetron which is used primarily as an aniemetic for those receiving chemo. However, it is indicated as useful as an anti-panic, anti-anxiety agent. Anyone have any experience with this? It's manufactured by Glaxo as Zoran at $40 per pill!
Posted by utopizen on August 18, 2002, at 13:27:48
In reply to Ondansetron for panic, GAD, social phobia , posted by LLL on August 17, 2002, at 19:43:27
Ondansetron May Reduce Craving Used to Prevent Nausea in Cancer Patients
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A drug currently used to fight nausea in cancer patients may help the hardest to treat alcoholics reduce their drinking, according to new research.http://alcoholism.about.com/library/weekly/aa001120a.htm
they should dispense this stuff to incoming freshman...
Posted by LLL on August 18, 2002, at 13:33:37
In reply to add alcohol craving reduction to that..., posted by utopizen on August 18, 2002, at 13:27:48
J Clin Psychiatry 1997;58 Suppl 5:50-4 Related Articles, Books, LinkOut
Role of serotonin drugs in the treatment of social phobia.Tancer ME, Uhde TW.
Psychiatry Service, Detroit Veterans Affairs Medical Center, MI 48201, USA.Social phobia is a common anxiety disorder that is underdiagnosed and undertreated. To date, three classes of serotonin drugs have been used to treat patients suffering from social phobia. These include the serotonin selective reuptake inhibitors (SSRIs), the partial 5-HT1A agonist buspirone, and the 5-HT3 antagonist ondansetron. Although none of the serotonin agents have yet been directly compared with the gold standard monoamine oxidase inhibitor phenelzine or the high potency triazolobenzo-diazepines alprazolam or clonazepam, the SSRIs, as a class, appear to be clinically useful agents. Further studies using larger sample sizes and double-blind methodology are needed to clarify the role of serotonin drugs in the treatment of social phobia.
Physical Symptoms Associated With Social Phobia - CME Reviews (Full article here)
Highlight the frequency and importance of social phobic physical symptoms
Review the literature on the specific treatment of physical symptoms in social phobia
Propose strategies for augmenting the partial response often found in social phobia treatment
Blushing
Blushing, or flushing -- as well as a fear of blushing -- has been noted to be a prevalent and psychologically debilitating condition.14 Charles Darwin was the pioneer who related blushing to social anxiety: "The thinking of others thinking of us . . . excites a blush. Most persons, while blushing intensely, have their mental powers confused. They lose their presence of mind and utter singularly inappropriate remarks."15Goldstein16 reported that clonidine was successfully used to treat a patient with social phobia and blushing, when treatment with alprazolam, phenelzine, and propranolol failed. Clonidine has also been used to treat the vasomotor instability associated with menopause,17 with variable results, in a dosage range of 0.05-0.15 mg/day. Goldstein's patient with social phobia16 took 0.1 mg bid with continued benefit at 4-month follow-up. Limiting side effects can include orthostatic hypotension, sedation, depression, fatigue, and gastrointestinal upset.
16) Goldstein S. Treatment of social phobia with clonidine. Biol Psychiatry. 1987;22:369-372.
Nausea
Ondansetron, an antiemetic with anxiolytic properties, has been shown to be effective for treatment of social phobia in a double-blind, placebo-controlled study.30 Although Ondansetron might be ideal in social phobia-related nausea, its cost is prohibitive.
30) DeVaugh-Geiss J, Bell J. Multicenter trial of a 5-HT3 antagonist, ondansetron, in social phobia (poster). Presented at: Annual Meeting of the American College of Neuropsychopharmacology; December 1994; San Juan, Puerto Rico.Anxiety 1996;2(4):199-202 Related Articles, Books, LinkOut
Ondansetron in the treatment of panic disorder.Schneier FR, Garfinkel R, Kennedy B, Campeas R, Fallon B, Marshall R, O'Donnell L, Hogan T, Liebowitz MR.
Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, NY 10032, USA.
PMID: 9160623 [PubMed - indexed for MEDLINE]
Anxiety Disorders Clinic
Michael R. Liebowitz, M.D., Director4/2/2001 (http://www.nyspi.org/development/web/rs2.htm):
"A number of specific areas of study within the Anxiety Disorders CIinic have been quite active:
Panic Disorder During the past year, the Anxiety Disorders Clinic, as part of a full Phase-III development program, completed two multi-center, industry-supported, double-blind efficacy and safety trials of the 5HT3 antagonist ondansetron. To date, ondansetron is the most pharmacologically specific anti-panic agent to be developed. Positive results would provide us with a better understanding of the mechanisms of anti-panic drug action. Results of the studies are now being analyzed.
Anxiety Disorders Clinic (http://www.nyspi.org/development/web/pidpt%5Ft.htm):
The Anxiety Disorders Clinic has continued its work to advance an understanding of the diagnosis, etiology, and treatment of DSM-IV anxiety disorders. Efforts have been particularly concentrated on panic disorder and agoraphobia, social phobia, obsessive-
compulsive disorder (OCD), generalized anxiety, hypochondriasis, post-traumatic stress disorder, and new areas of research activity involving the neuropsychiatric sequelae of Lyme disease, mixed anxiety and depression, and cross-cultural studies.
Panic Disorder An open trial of the 5HT3 antagonist ondansetron was completed in the earlier part of the year, under the direction of Dr. Michael Liebowitz. Results from this pilot were so favorable that a multi-center, industry supported, double-blind efficacy trial was initiated, which confirmed our findings. A full Phase-III development program is now under way in which we are participating. Ondansetron may work faster and be better tolerated than existing anti-panic medication treatments. A multi-center trial of sertraline in panic disorder has also begun in our clinic. "Sertraline has been approved for anxiety disorders for years now so what happened to ondansetron? Marketing decision perhaps as SSRIs reign through their product cycle. It's unfortunate ondansetron commonly sells for $40/pill in the US (price based on lower volume sales of limited indications & the country's price regulations) as it has been reported effective for hard to treat conditions such as refractory anxiety disorders, withdrawal and pain syndromes, fibromyalgia, gastrointestinal motility disorders, Tourette's syndrome, pruritus, flushing disorders and erythemateous rosacea & ocular rosacea.
Like other SSAs (Selective Serotonin Antagonists), it has a much lower incidence of sexual side effects than SSRIs.
This is the end of the thread.
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