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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by katekite on August 7, 2002, at 21:12:57
I came across this:
"Abrupt discontinuation of venlafaxine is not recommended due to its structural similarity to phencyclidine (PCP). If therapy with venlafaxine is > 1 week the dose should be tapered over 7-10 day to prevent a withdrawal syndrome (headache, nausea, dizziness, insomnia and nervousness)."
(First of all, hah hah at 7-10 days.)
Does anyone know if that is true and if that is really the reason effexor withdrawal is so bad? Or could it be some other reason?
Posted by oracle on August 7, 2002, at 21:17:01
In reply to effexor similarity to PCP as cause of withdrawal? , posted by katekite on August 7, 2002, at 21:12:57
Contex would help, where did this phrase come from ?
Posted by Ritch on August 8, 2002, at 1:43:49
In reply to Re: effexor similarity to PCP as cause of withdrawal? , posted by oracle on August 7, 2002, at 21:17:01
> Contex would help, where did this phrase come from ?
Yeah,
That would help a lot. I took PCP in high school, and Effexor doesn't feel anything like it.
Posted by katekite on August 8, 2002, at 8:43:47
In reply to effexor similarity to PCP as cause of withdrawal? , posted by katekite on August 7, 2002, at 21:12:57
http://www.vh.org/Providers/Conferences/CPS/15.html
{seems to be sponsored by U of Iowa}
--------
Clinical Psychopharmacology Seminar
Venlafaxine (Effexor®)
Original Author: Vicki Ellingrod, Pharm.D., BCPP
Latest Reviser: Vicki Ellingrod, Pharm.D., BCPP
Creation Date: 1996
Peer Review Status: Internally Peer Reviewed
Posted by Ritch on August 8, 2002, at 10:06:48
In reply to context, posted by katekite on August 8, 2002, at 8:43:47
> http://www.vh.org/Providers/Conferences/CPS/15.html
>
> {seems to be sponsored by U of Iowa}
>
> --------
>
> Clinical Psychopharmacology Seminar
>
> Venlafaxine (Effexor®)
> Original Author: Vicki Ellingrod, Pharm.D., BCPP
> Latest Reviser: Vicki Ellingrod, Pharm.D., BCPP
> Creation Date: 1996
> Peer Review Status: Internally Peer Reviewed
>
Kate,Thanks for that article. Unfortunately, being "structurally similar" to PCP isn't elucidated in the article (as to why Effexor shouldn't we withdrawn suddenly). I also read somewhere about buspirone (Buspar) being structurally similar to haloperidol (Haldol). Obviously Haldol and Buspar have more differing actions than similar ones. This makes me curious about the mechanisms of PCP withdrawal now and how that fits in?
Mitch
Posted by oracle on August 8, 2002, at 10:16:55
In reply to Re: effexor similarity to PCP as cause of withdrawal? » oracle, posted by Ritch on August 8, 2002, at 1:43:49
And the other indole hallucinogens, so it goes without saying that the AD's share this aspect, also.
DMT is a hallucinogen and a NT.
Posted by Ritch on August 9, 2002, at 0:22:48
In reply to NT's are structurally similar to LSD, posted by oracle on August 8, 2002, at 10:16:55
> And the other indole hallucinogens, so it goes without saying that the AD's share this aspect, also.
>
> DMT is a hallucinogen and a NT.
>
>Oracle,
You are guilty of your own original context question! What is an "NT"? I have noticed that the SSRI's and Effexor have this quality to produce very subtle visual illusions at night. On Prozac, this was not quite so subtle. I was driving down a deserted country highway at night and my truck elevated about 30 foot in the air and I had a mild panic attack, and had some difficulty driving for a few miles. VERY weird. Also, I notice that if I look at a red LED display at night on a higher dose of SSRI that I see all sorts of red, blue, green, "fluttery" colors waving away from the clock face... Nothing very alarming, but present. Also, on Prozac I could close my eyes, while I was trying to sleep and could see all sorts of luminous jellyfish type things floating all about like being inside a very dim lava lamp.
Mitch
Posted by oracle on August 9, 2002, at 18:28:16
In reply to Re: NT's are structurally similar to LSD » oracle, posted by Ritch on August 9, 2002, at 0:22:48
> Oracle,
>
> You are guilty of your own original context question! What is an "NT"?The context is this board, it is a term we use often here.
Posted by Ritch on August 9, 2002, at 23:40:01
In reply to Re: NT's are structurally similar to LSD, posted by oracle on August 9, 2002, at 18:28:16
> > Oracle,
> >
> > You are guilty of your own original context question! What is an "NT"?
>
> The context is this board, it is a term we use often here.Oh, you mean neurotransmitter. Effexor isn't a neurotransmitter, just a drug that affects neurotransmitters. That's what got me confused.
Mitch
This is the end of the thread.
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