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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by Jackster on September 10, 2001, at 5:06:25
Specifically the fatigue caused by clomipramine - is it usual for this sort of side effect to wear off after a few weeks?
Jackie
Posted by stjames on September 10, 2001, at 22:16:56
In reply to Do Tricyclic side effects wear off?, posted by Jackster on September 10, 2001, at 5:06:25
> Specifically the fatigue caused by clomipramine - is it usual for this sort of side effect to wear off after a few weeks?
>
> JackieYes, this is very common. I was on TCA's for years. Most knock you on your ass the first few
weeks. Then the antidepressant effects kick in (hopefully) and you are not tired anymore.James
Posted by Elizabeth on September 11, 2001, at 14:56:06
In reply to Do Tricyclic side effects wear off?, posted by Jackster on September 10, 2001, at 5:06:25
> Specifically the fatigue caused by clomipramine - is it usual for this sort of side effect to wear off after a few weeks?
Fatigue, possibly. I think that different people adapt to drug effects to different degrees. Such adaptation can prove an advantage in responding to toxicity, but a disadvantage in promoting tolerance.
-elizabeth
Posted by Elizabeth on September 11, 2001, at 14:56:58
In reply to Re: Do Tricyclic side effects wear off?, posted by stjames on September 10, 2001, at 22:16:56
> Yes, this is very common. I was on TCA's for years. Most knock you on your ass the first few
> weeks. Then the antidepressant effects kick in (hopefully) and you are not tired anymore.FWIW, desipramine doesn't seem to cause any sedation at all, and it was only mild with the other two TCAs I've tried (nortriptyline and amoxapine).
-e
Posted by angel1 on September 11, 2001, at 20:40:49
In reply to Re: Do Tricyclic side effects wear off? » stjames, posted by Elizabeth on September 11, 2001, at 14:56:58
HI Elizabeth. how is the desipramine working for
you? Do you feel better and what dosage are you on.Thanks Tamara. I used it for a while, but it seemed like it took at least six weeks for it to work.
I only took 25-50mg. too high a dose made my nose turn red, my lower eyelids twitched as well.
Posted by MB on September 12, 2001, at 1:40:15
In reply to Re: Do Tricyclic side effects wear off? » stjames, posted by Elizabeth on September 11, 2001, at 14:56:58
Can you tolorate H-1 blockade pretty well in general? For me, anything that blocks H-1 knocks me on my butt (and that goes equally for the drugs that "don't cross the blood-brain barrier" like Zyrtec). Is it just your body's response to H-1 blockade? My dad, for example, can take Benadryl and go about his day like it was nothing but a sugar pill. Or, is there something unique about the tricyclics that make you impervious to the sedation?
> FWIW, desipramine doesn't seem to cause any sedation at all, and it was only mild with the other two TCAs I've tried (nortriptyline and amoxapine).
>
> -e
Posted by Elizabeth on September 12, 2001, at 4:58:18
In reply to Re: Do Tricyclic side effects wear off?, posted by angel1 on September 11, 2001, at 20:40:49
> HI Elizabeth. how is the desipramine working for
> you? Do you feel better and what dosage are you on.I dropped to 225 and then 200 because of high serum levels. I'm doing all right on it, together with buprenorphine. With desipramine alone, I still felt a lot of fatigue and lack of motivation.
> I only took 25-50mg. too high a dose made my nose turn red, my lower eyelids twitched as well.
That's weird! Did you have any itching or dry eyes/blurred vision?
-elizabeth
Posted by Elizabeth on September 12, 2001, at 5:00:24
In reply to Re: Do Tricyclic side effects wear off? » Elizabeth, posted by MB on September 12, 2001, at 1:40:15
> Can you tolorate H-1 blockade pretty well in general?
Yeah, I don't tend to get sedated or dysphoric on antihistamines (Benadryl, Atarax, etc.).
> For me, anything that blocks H-1 knocks me on my butt (and that goes equally for the drugs that "don't cross the blood-brain barrier" like Zyrtec). Is it just your body's response to H-1 blockade? My dad, for example, can take Benadryl and go about his day like it was nothing but a sugar pill. Or, is there something unique about the tricyclics that make you impervious to the sedation?
I think it's at least in part because the TCAs I tried have relatively little histamine-blocking effect.
-elizabeth
Posted by stjames on September 12, 2001, at 16:26:42
In reply to Re: Do Tricyclic side effects wear off? » stjames, posted by Elizabeth on September 11, 2001, at 14:56:58
> FWIW, desipramine doesn't seem to cause any sedation at all, and it was only mild with the other two TCAs I've tried (nortriptyline and amoxapine).
>
> -eAll of these knock some people out, at first.
Posted by Elizabeth on September 12, 2001, at 21:34:17
In reply to Re: Do Tricyclic side effects wear off?, posted by stjames on September 12, 2001, at 16:26:42
> > FWIW, desipramine doesn't seem to cause any sedation at all, and it was only mild with the other two TCAs I've tried (nortriptyline and amoxapine).
>
> All of these knock some people out, at first.I think it's extremely rare with desipramine, and the sedation is more commonly moderate than extreme with the other two.
-e
Posted by angel1 on September 12, 2001, at 22:33:58
In reply to Re: Do Tricyclic side effects wear off?, posted by angel1 on September 11, 2001, at 20:40:49
hi elizabeth. I also lost weight on desipramine
without even trying. I am thin to begin with, so I didn't really need to lost weight, but i could eat whatever I wanted. I was never tired when I
was on it which was nice. I suffer from chronic
dysthymia. What is your diagnosis?
Posted by stjames on September 13, 2001, at 11:56:34
In reply to Re: Do Tricyclic side effects wear off? » stjames, posted by Elizabeth on September 12, 2001, at 21:34:17
> > > FWIW, desipramine doesn't seem to cause any sedation at all, and it was only mild with the other two TCAs I've tried (nortriptyline and amoxapine).
> >
> > All of these knock some people out, at first.
>
> I think it's extremely rare with desipramine, and the sedation is more commonly moderate than extreme with the other two.
>
> -eJames here....
I can only speak from personal experience, having
having tried all of these.james
This is the end of the thread.
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