Psycho-Babble Medication Thread 53513

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SSRIs and emotion

Posted by martin on February 8, 2001, at 10:11:05

does anyone know the mechanism responsible for SSRIs (sertraline in my case) thymoanaesthetic effects? and how to attenuate them?

read lots about the potential of dopaminergic drugs to counteract this effect, but contrary to the US indirect sympathomimetics like methylphenidate or dextroamphetamine are not prescribed by european physicians very often.

so what remains are dopamine-receptor-agonists like the ergot-derivates bromergocrytine and lisuride, but these drugs always cause (severe)nausea etc.

any recommendations?
thanks

Re: SSRIs and emotion

Posted by SalArmy4me on February 8, 2001, at 16:06:55

In reply to SSRIs and emotion, posted by martin on February 8, 2001, at 10:11:05

I'm on pramipexole and haven't noticed any nausea.

> does anyone know the mechanism responsible for SSRIs (sertraline in my case) thymoanaesthetic effects? and how to attenuate them?
>
> read lots about the potential of dopaminergic drugs to counteract this effect, but contrary to the US indirect sympathomimetics like methylphenidate or dextroamphetamine are not prescribed by european physicians very often.
>
> so what remains are dopamine-receptor-agonists like the ergot-derivates bromergocrytine and lisuride, but these drugs always cause (severe)nausea etc.
>
> any recommendations?
> thanks

Re: SSRIs and emotion

Posted by AndrewB on February 8, 2001, at 22:15:04

In reply to SSRIs and emotion, posted by martin on February 8, 2001, at 10:11:05

Mirapex (pramipexole), a D2/D3 agonist, is available in Europe. Is effective as an add-on on to SSRIs. May very well relive the symtoms you talk about. Nausea, often transient, is common but can be conteracted with the periphereal dopaminergic domperidone, also available in Europe.

Pindolol and Buspirone as an add on can, I beieve also effectively counteract the symtom you describe. Dosage to 20mg. buspirone for week one and 30mg/day thereafter and 2.5 mg. of buspirone taken three times a day.

These are available in Europe also.

AndrewB

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