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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by mat on October 20, 1999, at 13:00:33
My psych has just prescibed me with Manerix/Moclobemide after failed attempts with prozac and effexor. Has anyone out there ever taken Manerix/Moclobemide and if so ???????
Any info would be gratefully recieved
Posted by JohnL on October 20, 1999, at 17:29:06
In reply to Manerix/Moclobemide results? , posted by mat on October 20, 1999, at 13:00:33
> My psych has just prescibed me with Manerix/Moclobemide after failed attempts with prozac and effexor. Has anyone out there ever taken Manerix/Moclobemide and if so ???????
>
> Any info would be gratefully recievedI tried Moclobemide once. I was a rare statistic in having a very bad initial reaction at just 75mg. My doc stepped in immediately and took me off it after just 2 days. That's VERY rare. However, prior to this I studied and researched everywhere about Manerix. Here's what I found out.
Some docs say it's wonderful. Some say it's weak. But the general consensus was that it is most effective at the top of it's dosage range. It's even more effective higher than the stated maximum dose. Some docs go over the limit with good results and no adverse reactions. The "normal" doses probably aren't enough based on what I've read. So just be aware that in general, not always, it seems to be a drug where the highest tolerated dose is where you can expect good response.
Side effects are supposedly more tame than SSRIs. No diet problems either. A common early side effect is irritability or jitteriness that is said to disappear completely in a couple weeks with continued use. Like any drug, there's that hump to get over in the beginning. The doc I saw said he regularly adds small amounts of just about any other AD out there (except other MAOIs) if needed for potentiation. Of course the label warns against that, but in practice it is being done.
It's a shame the USA will never have this drug. The doc explained this to me. It's patend will soon expire. Then it will become generic. Companies don't want to spend the millions of dollars needed to push a drug through FDA trials when it's just going to be a generic. Could be a great drug for you. That's probably why your doc chose it.
Posted by Rick on October 20, 1999, at 19:12:22
In reply to Re: Manerix/Moclobemide results? , posted by JohnL on October 20, 1999, at 17:29:06
>It's a shame the USA will never have this drug. >The doc explained this to me. It's patent will >soon expire. Then it will become generic. >Companies don't want to spend the millions of
>dollars needed to push a drug through FDA trials
>when it's just going to be a generic. Could be a >great drug for you. That's probably why your doc
>chose it.This may be an oversimplification...but couldn't a company modify Moclobemide a bit and then get a new patent? Look at all the similar SSRI's out there. My pdoc feels that Selegiline (both the patch and the "doggie Alzheimer's" version) will renew interest in MAOI's among U.S. pharmaceutical companies.
Rick
Posted by Allen on January 17, 2000, at 23:27:38
In reply to Manerix/Moclobemide results? , posted by mat on October 20, 1999, at 13:00:33
> My psych has just prescibed me with Manerix/Moclobemide after failed attempts with prozac and effexor. Has anyone out there ever taken Manerix/Moclobemide and if so ???????
>
> Any info would be gratefully recievedI have been taking Aurorix (in Australia) Moclobemide for about 4 weeks. I am finding that I have more energy, am less depressed, and have noticed an improvement in mood swings. Am taking 450mg. As I understand it, and have researched this drug alot - It is very effective in doses 450mg and above. I am gradually trying to increase the dose to 600mg. It is a drug that works well - but you have to be patient with it. Best of luck.
Posted by MH on August 12, 2000, at 9:07:11
In reply to Re: Manerix/Moclobemide results? , posted by Allen on January 17, 2000, at 23:27:38
> > My psych has just prescibed me with Manerix/Moclobemide after failed attempts with prozac and effexor. Has anyone out there ever taken Manerix/Moclobemide and if so ???????
> >
> > Any info would be gratefully recieved
>
> I have been taking Aurorix (in Australia) Moclobemide for about 4 weeks. I am finding that I have more energy, am less depressed, and have noticed an improvement in mood swings. Am taking 450mg. As I understand it, and have researched this drug alot - It is very effective in doses 450mg and above. I am gradually trying to increase the dose to 600mg. It is a drug that works well - but you have to be patient with it. Best of luck.I, too, have taken Aurorix in Australia - the best of the ADs I have taken to date. Nil side effects (SSRIs intolerable for me) and started to feel quite "happy" after about a month on just 300 mg. No hassles with diet restrictions either. Had to go off it unfortunately as Dr went out of town and no scripts - will start on it again.
However, this is in addition to taking Doxepin at night for sleep and GAD (over the years and effective for me as well)+ xanax by day (low dose) for panics/agoraphobia. All in all, I found that while I was on the Aurorex, I could finish the pack, no sweat - something I could definitely not do with the SSRIs, Effexors, etc.
Posted by MH on August 12, 2000, at 9:20:12
In reply to Re: Manerix/Moclobemide results? , posted by MH on August 12, 2000, at 9:07:11
> > > My psych has just prescibed me with Manerix/Moclobemide after failed attempts with prozac and effexor. Has anyone out there ever taken Manerix/Moclobemide and if so ???????
> > >
> > > Any info would be gratefully recieved
> >
> > I have been taking Aurorix (in Australia) Moclobemide for about 4 weeks. I am finding that I have more energy, am less depressed, and have noticed an improvement in mood swings. Am taking 450mg. As I understand it, and have researched this drug alot - It is very effective in doses 450mg and above. I am gradually trying to increase the dose to 600mg. It is a drug that works well - but you have to be patient with it. Best of luck.
>
> I, too, have taken Aurorix in Australia - the best of the ADs I have taken to date. Nil side effects (SSRIs intolerable for me) and started to feel quite "happy" after about a month on just 300 mg. No hassles with diet restrictions either. Had to go off it unfortunately as Dr went out of town and no scripts - will start on it again.
> However, this is in addition to taking Doxepin at night for sleep and GAD (over the years and effective for me as well)+ xanax by day (low dose) for panics/agoraphobia. All in all, I found that while I was on the Aurorex, I could finish the pack, no sweat - something I could definitely not do with the SSRIs, Effexors, etc.Further to my earlier email, I forgot to mention that I believe the FDA are seriously looking at approving Brofaromine (very similar to Manerix) as an alternative; which could happen soon.
Posted by Anna P. on August 12, 2000, at 12:20:11
In reply to Re: Manerix/Moclobemide results? , posted by MH on August 12, 2000, at 9:07:11
> > > My psych has just prescibed me with Manerix/Moclobemide after failed attempts with prozac and effexor. Has anyone out there ever taken Manerix/Moclobemide and if so ???????
> > >
> > > Any info would be gratefully recieved
> >
> > I have been taking Aurorix (in Australia) Moclobemide for about 4 weeks. I am finding that I have more energy, am less depressed, and have noticed an improvement in mood swings. Am taking 450mg. As I understand it, and have researched this drug alot - It is very effective in doses 450mg and above. I am gradually trying to increase the dose to 600mg. It is a drug that works well - but you have to be patient with it. Best of luck.
>
> I, too, have taken Aurorix in Australia - the best of the ADs I have taken to date. Nil side effects (SSRIs intolerable for me) and started to feel quite "happy" after about a month on just 300 mg. No hassles with diet restrictions either. Had to go off it unfortunately as Dr went out of town and no scripts - will start on it again.
> However, this is in addition to taking Doxepin at night for sleep and GAD (over the years and effective for me as well)+ xanax by day (low dose) for panics/agoraphobia. All in all, I found that while I was on the Aurorex, I could finish the pack, no sweat - something I could definitely not do with the SSRIs, Effexors, etc.Hello there,
I took Moclobemide succesfully for some time. It can be used up to
900 mg. Also, I have all info on augmentation of it, when it poops out.
MH, since you live in Australia, do you have over there Minalcipram (brand name Dalcipran or Ixel). It's a SNRI with no sexual side effects. I will appreciate your response.Anna
Posted by MH on August 13, 2000, at 9:37:55
In reply to Re: Manerix/Moclobemide results? , posted by Anna P. on August 12, 2000, at 12:20:11
> > > > My psych has just prescibed me with Manerix/Moclobemide after failed attempts with prozac and effexor. Has anyone out there ever taken Manerix/Moclobemide and if so ???????
> > > >
> > > > Any info would be gratefully recieved
> > >
> > > I have been taking Aurorix (in Australia) Moclobemide for about 4 weeks. I am finding that I have more energy, am less depressed, and have noticed an improvement in mood swings. Am taking 450mg. As I understand it, and have researched this drug alot - It is very effective in doses 450mg and above. I am gradually trying to increase the dose to 600mg. It is a drug that works well - but you have to be patient with it. Best of luck.
> >
> > I, too, have taken Aurorix in Australia - the best of the ADs I have taken to date. Nil side effects (SSRIs intolerable for me) and started to feel quite "happy" after about a month on just 300 mg. No hassles with diet restrictions either. Had to go off it unfortunately as Dr went out of town and no scripts - will start on it again.
> > However, this is in addition to taking Doxepin at night for sleep and GAD (over the years and effective for me as well)+ xanax by day (low dose) for panics/agoraphobia. All in all, I found that while I was on the Aurorex, I could finish the pack, no sweat - something I could definitely not do with the SSRIs, Effexors, etc.
>
> Hello there,
>
> I took Moclobemide succesfully for some time. It can be used up to
> 900 mg. Also, I have all info on augmentation of it, when it poops out.
> MH, since you live in Australia, do you have over there Minalcipram (brand name Dalcipran or Ixel). It's a SNRI with no sexual side effects. I will appreciate your response.
>
> AnnaAnna
It's a new one on me, however, I think the closest med we come to that in Australia is Effexor (Venlaxafine). I assume that milnacipran (ixel) is used or still being studied in Europe (unsure), but, to the best of my knowledge, not approved here as yet.
Appreciate it if you could provide the augmentation info on Moclobemide that you mentioned.
Many tks
MH
Posted by Anna P. on August 14, 2000, at 12:20:11
In reply to Re: Manerix/Moclobemide results? , posted by MH on August 13, 2000, at 9:37:55
> > > > >
> Anna
> It's a new one on me, however, I think the closest med we come to that in Australia is Effexor (Venlaxafine). I assume that milnacipran (ixel) is used or still being studied in Europe (unsure), but, to the best of my knowledge, not approved here as yet.
> Appreciate it if you could provide the augmentation info on Moclobemide that you mentioned.
> Many tks
> MHHello MH,
What I try was:
Aurorex + Dexedrine
Aurorex + Revia (Naltrexone)* (the best)
Aurorex + Revia + CytomelYou can find a lot of information about Naltrexone in other threads, and dr Bob's tips
Anna
Posted by MH on August 15, 2000, at 5:41:01
In reply to Re: Manerix/Moclobemide results? , posted by Anna P. on August 14, 2000, at 12:20:11
> > > > > >
> > Anna
> > It's a new one on me, however, I think the closest med we come to that in Australia is Effexor (Venlaxafine). I assume that milnacipran (ixel) is used or still being studied in Europe (unsure), but, to the best of my knowledge, not approved here as yet.
> > Appreciate it if you could provide the augmentation info on Moclobemide that you mentioned.
> > Many tks
> > MH
>
> Hello MH,
> What I try was:
> Aurorex + Dexedrine
> Aurorex + Revia (Naltrexone)* (the best)
> Aurorex + Revia + Cytomel
>
> You can find a lot of information about Naltrexone in other threads, and dr Bob's tips
>
> AnnaAnna
Phew..there's some there, I have never heard of any of this stuff - what's Naltrexone??
MH
Posted by Anna P. on August 15, 2000, at 10:59:35
In reply to Re: Manerix/Moclobemide results? , posted by MH on August 15, 2000, at 5:41:01
> > > > > > >
> > > Anna
> > > It's a new one on me, however, I think the closest med we come to that in Australia is Effexor (Venlaxafine). I assume that milnacipran (ixel) is used or still being studied in Europe (unsure), but, to the best of my knowledge, not approved here as yet.
> > > Appreciate it if you could provide the augmentation info on Moclobemide that you mentioned.
> > > Many tks
> > > MH
> >
> > Hello MH,
> > What I try was:
> > Aurorex + Dexedrine
> > Aurorex + Revia (Naltrexone)* (the best)
> > Aurorex + Revia + Cytomel
> >
> > You can find a lot of information about Naltrexone in other threads, and dr Bob's tips
> >
> > Anna
>
> Anna
> Phew..there's some there, I have never heard of any of this stuff - what's Naltrexone??
> MHMH,
Naltrexone was a miracle pill for me. It's used for alkoholics by working on the opiate system.
Also, it's used as augmentation agent for people that loose response to antidepressants. There is a thread in Dr Bob's tips about loosing response to antidepressants.
And, trust me, it really works. You need to start from very little dose until your body adjustes (about 4 mg) and increase the doze slowly.
It combines well with Aurorex.Anna P.
Posted by MH on August 17, 2000, at 8:30:40
In reply to Re: Manerix/MH , posted by Anna P. on August 15, 2000, at 10:59:35
> > > > > > > >
> > > > Anna
> > > > It's a new one on me, however, I think the closest med we come to that in Australia is Effexor (Venlaxafine). I assume that milnacipran (ixel) is used or still being studied in Europe (unsure), but, to the best of my knowledge, not approved here as yet.
> > > > Appreciate it if you could provide the augmentation info on Moclobemide that you mentioned.
> > > > Many tks
> > > > MH
> > >
> > > Hello MH,
> > > What I try was:
> > > Aurorex + Dexedrine
>
>
>
>
> > > Aurorex + Revia (Naltrexone)* (the best)
> > > Aurorex + Revia + Cytomel
> > >
> > > You can find a lot of information about Naltrexone in other threads, and dr Bob's tips
> > >
> > > Anna
> >
> > Anna
> > Phew..there's some there, I have never heard of any of this stuff - what's Naltrexone??
> > MH
>
> MH,
> Naltrexone was a miracle pill for me. It's used for alkoholics by working on the opiate system.
> Also, it's used as augmentation agent for people that loose response to antidepressants. There is a thread in Dr Bob's tips about loosing response to antidepressants.
> And, trust me, it really works. You need to start from very little dose until your body adjustes (about 4 mg) and increase the doze slowly.
> It combines well with Aurorex.
>
> Anna P.Ok ~ tks, will keep in mind (if it is approved in this country....??)
Posted by dave_fox on June 3, 2001, at 12:55:13
In reply to Re: Manerix/Moclobemide results? , posted by Anna P. on August 12, 2000, at 12:20:11
>
> Hello there,
>
> I took Moclobemide succesfully for some time. > It can be used up to
> 900 mg. Also, I have all info on augmentation > of it, when it poops out.
>
> [snip] [snip]
>
> AnnaAnna, I would really appeciate it if you could post some links to where I can read about Moclobemide poop-out. Thank you very much.
BF
Posted by SLS on June 3, 2001, at 14:01:07
In reply to Re: Manerix/Moclobemide results? , posted by dave_fox on June 3, 2001, at 12:55:13
> Anna, I would really appeciate it if you could post some links to where I can read about Moclobemide poop-out. Thank you very much.
>
> BF
Hi BF.Are you currently taking moclobemide? At what dosage? How long have you been taking it? What are you being treated for?
I am also interested in what strategies are commonly used to compensate for moclobemide poop-out. Moclobemide is notorious for requiring higher and higher dosages to maintain its therapeutic effect. Some people take 1200mg and higher. I don't often read of it being used successfully for the more severe depressions. However, I sometimes encounter stories of people with more moderate depressions or social anxiety who do well on it. It produces a therapeutic effect very quickly - often in the first week. For most people, moclobemide is almost without side effects. In Finland, it was the most often prescribed antidepressant, and may still be. In New Zealand, it fell from being prescribed often as a first choice to not being prescribed at all for lack of efficacy.
If you are unable to recapture an antidepressant response to moclobemide by either raising the dosage or augmenting it with other drugs, you might consider trying Nardil. Nardil is a non-selective irreversable MAOI, so adhering to the special diet will be necessary. I have been on and off the diet for years. It is not such a big deal. My gut feeling is that Nardil is more similar to moclobemide than is Parnate. Perhaps Parnate does not inhibit MAO-A to the same degree as does Nardil or moclobemide.
Moclobemide can work miracles for some people. I hope you are one of them.
Good luck.
- Scott
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