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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 38. This is the beginning of the thread.
Posted by Jeroen on November 22, 2018, at 5:29:26
Hi, my pdoc agreed to prescribe me Asenapine on top off abilify clonazepam and nobiten
for depression and paranoia left over negative symptoms, what is your idea on that, ive asked him myself
Posted by SLS on November 22, 2018, at 5:37:09
In reply to Asenapine to anyone who can help me please, posted by Jeroen on November 22, 2018, at 5:29:26
> Hi, my pdoc agreed to prescribe me Asenapine on top off abilify clonazepam and nobiten
>
>
> for depression and paranoia left over negative symptoms, what is your idea on that, ive asked him myselfYes, asenapine (Saphris) can treat all of those symptoms. My friend responds well to it.
- Scott
Posted by Jeroen on November 22, 2018, at 7:07:42
In reply to Re: Asenapine to anyone who can help me please, posted by SLS on November 22, 2018, at 5:37:09
Hey Scott
thanks for your reply :)
i care about you too, is it ok to take saphris 5mg once daily at night or do i need it twice
Posted by SLS on November 22, 2018, at 8:38:53
In reply to Re: Asenapine to anyone who can help me please, posted by Jeroen on November 22, 2018, at 7:07:42
> Hey Scott
>
> thanks for your reply :)
>
> i care about you too, is it ok to take saphris 5mg once daily at night or do i need it twiceI tried Saphris earlier this year. I took it twice a day as described in the manufacturer's package label.
- Scott
Posted by Jeroen on November 22, 2018, at 10:23:51
In reply to Re: Asenapine to anyone who can help me please, posted by SLS on November 22, 2018, at 8:38:53
twice did you sleep a lot Scott?
Posted by SLS on November 22, 2018, at 11:12:43
In reply to Re: Asenapine to anyone who can help me please, posted by Jeroen on November 22, 2018, at 10:23:51
> twice did you sleep a lot Scott?
No. Asenapine didn't affect my sleep at all.
- Scott
Posted by Jeroen on November 22, 2018, at 11:14:07
In reply to Re: Asenapine to anyone who can help me please, posted by SLS on November 22, 2018, at 11:12:43
sedation?
Posted by SLS on November 22, 2018, at 20:09:47
In reply to Re: Asenapine to anyone who can help me please, posted by Jeroen on November 22, 2018, at 11:14:07
> sedation?
Not really. Maybe a little for the first few days.
- Scott
Posted by linkadge on November 25, 2018, at 13:25:51
In reply to Asenapine to anyone who can help me please, posted by Jeroen on November 22, 2018, at 5:29:26
Hi Jaroen,
I think this is a good idea. Asenapine acts as both an antidepressant / antipsychotic. It also has neurotrophic effects, which many antipsychotics do not, so (in theory) it may could positive effects on memory / cognition over time.
Linkadge
Posted by Jeroen on November 25, 2018, at 16:18:09
In reply to Re: Asenapine to anyone who can help me please, posted by SLS on November 22, 2018, at 20:09:47
Some say i can take my dose once at night
Im on abilify 25 mg. Clonazepam 1 mg twice. Nobiten 5 mg
Posted by linkadge on November 25, 2018, at 17:58:44
In reply to Re: Asenapine to anyone who can help me please, posted by Jeroen on November 25, 2018, at 16:18:09
Yeah, you could certainly try it at night (start low and go slow). It has some effects as an antihistamine, but it is not as strong in this regard as amitriptyline or doxepin.
Long term, you probably won't find it super sedating.
Linkadge
Posted by Jeroen on November 25, 2018, at 18:40:05
In reply to Re: Asenapine to anyone who can help me please, posted by linkadge on November 25, 2018, at 17:58:44
Am i allowed to split pill into half too or not?
Posted by linkadge on November 26, 2018, at 15:59:06
In reply to Re: Asenapine to anyone who can help me please lin, posted by Jeroen on November 25, 2018, at 18:40:05
It's your body.
I often split pills when starting a medication (to allow a slower taper). If you end up taking less than prescribed, just tell your doctor.
For example, amitriptyline comes in 10mg (smallest dose), but I increased by 5mg, as I am sensitive.
Linkadge
Posted by Jeroen on November 30, 2018, at 5:04:41
In reply to Re: Asenapine to anyone who can help me please lin, posted by linkadge on November 26, 2018, at 15:59:06
from people whove taken it the manufacterer said
Posted by linkadge on December 7, 2018, at 17:56:48
In reply to youre not supposed to split saphris pills i heared, posted by Jeroen on November 30, 2018, at 5:04:41
Hmm. I'm not sure why you can't split the pills.
They may say this because it is on patent, and splitting pills (i.e. buying double the dose and cutting it in half) can save people money.
Splitting may cause the drug to release faster, but it has a fairly long half life (24 hours) so, it should last a full day whether it releases slowly or more quickly.
Linkadge
Posted by SLS on December 8, 2018, at 12:50:22
In reply to Re: youre not supposed to split saphris pills i heared, posted by linkadge on December 7, 2018, at 17:56:48
> Hmm. I'm not sure why you can't split the pills.
>
> They may say this because it is on patent, and splitting pills (i.e. buying double the dose and cutting it in half) can save people money.
>
> Splitting may cause the drug to release faster, but it has a fairly long half life (24 hours) so, it should last a full day whether it releases slowly or more quickly.
>
> LinkadgeAfter the seal is broken and the tablet removed, you can put the remainder in the refrigerator.
- Scott
Posted by Jeroen on December 8, 2018, at 13:32:30
In reply to Re: youre not supposed to split saphris pills i heared, posted by SLS on December 8, 2018, at 12:50:22
Day 9 saphris
Posted by Jeroen on December 8, 2018, at 16:04:38
In reply to To SLS, posted by Jeroen on December 8, 2018, at 13:32:30
Its starting to work a bit on my negative symptoms Day 9 so far
Posted by SLS on December 8, 2018, at 17:37:43
In reply to Re: To SLS, posted by Jeroen on December 8, 2018, at 16:04:38
> Its starting to work a bit on my negative symptoms Day 9 so far
That's good news. I hope it continues.
- Scott
Posted by Jeroen on December 8, 2018, at 18:45:55
In reply to Re: To SLS » Jeroen, posted by SLS on December 8, 2018, at 17:37:43
Did you look into sarcosine?
Posted by SLS on December 9, 2018, at 10:04:47
In reply to Re: To SLS, posted by Jeroen on December 8, 2018, at 18:45:55
> Did you look into sarcosine?
I put sarcosine on my list of things to try after you mentioned it. I need to stabilize on Parnate first.
I did not respond to intranasal ketamine. Sarcosine's mechanisms of action include working in the opposite way of ketamine on NMDA receptors. Maybe that means that Sarcosine would be a good choice for me.
The more ideas, the better. I'm thinking of going on NAC (N-acetylcysteine). Both sarcosine and NAC treatments do not produce immediate results. A good trial of NAC can take months.Thanks.
- Scott
Posted by Lamdage22 on December 10, 2018, at 8:18:40
In reply to Re: To SLS » Jeroen, posted by SLS on December 9, 2018, at 10:04:47
That sounds good Scott. What dosage are you at? What dosage did you take before you withdrew?
Posted by Lamdage22 on December 10, 2018, at 8:23:53
In reply to Re: To SLS » Jeroen, posted by SLS on December 9, 2018, at 10:04:47
I had immediate results with both. NAC was pretty cool and strong for 2 days then i felt like absolute crap. Sarcosine made me better within days but i had akathisia.
There are many things to try, Scott, once you are somewhat restored by Parnate!
If you run out of ideas, i have plenty.
Posted by SLS on December 10, 2018, at 11:41:38
In reply to Re: To SLS, posted by Lamdage22 on December 10, 2018, at 8:18:40
> That sounds good Scott. What dosage are you at? What dosage did you take before you withdrew?
I was taking 80 mg/day of Parnate before stopping it. I went from 80-0 in two weeks. Not smart. I've done it before, though. The only negative effects in the past were profound fatigue and a worsening of depression.
I am hoping that I can take less now and still receive equal benefit. Maybe 40 mg/day.
- Scott
Posted by Lamdage22 on December 10, 2018, at 11:44:48
In reply to Re: To SLS » Lamdage22, posted by SLS on December 10, 2018, at 11:41:38
Do you have some benefit already? Speaking in percentage, what percentage were you at on Parnate back in the days and what percentage are you at now?
100%=remission?
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