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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 36. This is the beginning of the thread.
Posted by vbs on April 26, 2013, at 20:02:58
I am wondering if I'm on one too many meds. I was given my first injection of Invega Sustenna last Thurs and 2nd dose yesterday. I also take the following:
Zyprexa 20 mg
Saphris 10 mg
Cymbalta 60 mg
trazodone 50 mgAnd I'm still hearing voices! What's up w/ that? Any input / feedback on my drug cocktail would be appreciated.
Posted by Lou Pilder on April 26, 2013, at 20:28:54
In reply to Invega Sustenna and 4 other meds, posted by vbs on April 26, 2013, at 20:02:58
> I am wondering if I'm on one too many meds. I was given my first injection of Invega Sustenna last Thurs and 2nd dose yesterday. I also take the following:
>
> Zyprexa 20 mg
> Saphris 10 mg
> Cymbalta 60 mg
> trazodone 50 mg
>
> And I'm still hearing voices! What's up w/ that? Any input / feedback on my drug cocktail would be appreciated.vbs,
You wrote,[...if I am on one too many (drugs)...Any input..would be appreciated...].
The chemical composition of the drugs that you are taking when combined could cause death by heart attack and there are Central Nervous System depressants that could stop breathing and/or the heart. The drugs themselves could cause hallucinations and psychosis. They could also impair your thinking and increase suicidal thinking. Trying to stop taking the drugs could induce a state of mind to be compelled to kill yourself and/or others, even commit mass-murder.
I am prevented from posting here how you could be free from being scared of the drugs killing you, and have a new life, due to the prohibitions posted to me here by Mr. Hsiung, even though you asked for {any} feedback.
Lou
Posted by vbs on April 26, 2013, at 21:37:59
In reply to Lou's response-ewazedphaorit » vbs, posted by Lou Pilder on April 26, 2013, at 20:28:54
Thanks for your feedback, Lou. I sure hope that the drugs aren't causing my psychosis. I want to be free of the voices. Bottom line. My pdoc does plan to gradually taper me off of Zyprexa. I am concerned about drug-drug interactions.
Posted by vbs on April 26, 2013, at 21:46:33
In reply to Invega Sustenna and 4 other meds, posted by vbs on April 26, 2013, at 20:02:58
Posted by Phillipa on April 26, 2013, at 21:56:13
In reply to Re: Lou's response-ewazedphaorit, posted by vbs on April 26, 2013, at 21:37:59
Hi VBS did you ask your pharmacist if any interractions with the combo? Phillipa
Posted by SLS on April 26, 2013, at 23:12:03
In reply to Invega Sustenna and 4 other meds, posted by vbs on April 26, 2013, at 20:02:58
> I am wondering if I'm on one too many meds. I was given my first injection of Invega Sustenna last Thurs and 2nd dose yesterday. I also take the following:
>
> Zyprexa 20 mg
> Saphris 10 mg
> Cymbalta 60 mg
> trazodone 50 mg
>
> And I'm still hearing voices! What's up w/ that? Any input / feedback on my drug cocktail would be appreciated.You are not necessarily taking too many meds. You just might not be taking enough of the right meds. Have you tried one of the older AP drugs like Navane (thiothixene)? You might want to ask your doctor about substituting Zyprexa and Invega with Navane if the Invega doesn't work. I have seen a combination of Navane + Saphris work well to effectively resolve and prevent a delusional psychotic depression (schizoaffective disorder).
I'm sorry that you are still hearing voices.
What has you convinced that Cymbalta is the best antidepressant for you? Have you tried Wellbutrin?
- Scott
Posted by vbs on April 26, 2013, at 23:53:23
In reply to Re: Lou's response-ewazedphaorit » vbs, posted by Phillipa on April 26, 2013, at 21:56:13
> Hi VBS did you ask your pharmacist if any interractions with the combo? Phillipa
No. I'll call my pharmacist tomorrow. I did check for interactions at drugs.com though. Nothing significant except for *possible* interactions b/w trazodone and Cymbalta and b/w the 3 atypical antipsychotics. I don't know I just don't feel good. Sucks! The voices seem to be fading away though. So that much is positive.
Posted by vbs on April 27, 2013, at 4:58:23
In reply to Re: Invega Sustenna and 4 other meds » vbs, posted by SLS on April 26, 2013, at 23:12:03
Hi SLS, no I haven't tried an older AP. The good news is that the voices are almost gone now. The voices come & go. And I want to agree w/ you - I'm not necessarily on too many meds. Apparently it takes time for Invega Sustenna to work. I've only been on it for nine days. And yes, I've tried Wellbutrin. It aggravated my condition. Thanks for replying.
Posted by SLS on April 27, 2013, at 7:46:31
In reply to Re: Invega Sustenna and 4 other meds » SLS, posted by vbs on April 27, 2013, at 4:58:23
> Hi SLS, no I haven't tried an older AP. The good news is that the voices are almost gone now.
Yay!
It would nice to be able to jettison the Zyprexa if body weight and diabetes become issues. There is no guarantee that you will do well without it, but it might be worth a try, now that the Invega is working to reduce schizoid symptoms. I would keep the Saphris, as it can contribute to producing an antidepressant and mild energizing effect.
> And yes, I've tried Wellbutrin. It aggravated my condition.
That's what I figured. Thanks for the feedback.
- Scott
Posted by Lou Pilder on April 27, 2013, at 8:57:05
In reply to Re: » Phillipa, posted by vbs on April 26, 2013, at 23:53:23
> > Hi VBS did you ask your pharmacist if any interractions with the combo? Phillipa
>
> No. I'll call my pharmacist tomorrow. I did check for interactions at drugs.com though. Nothing significant except for *possible* interactions b/w trazodone and Cymbalta and b/w the 3 atypical antipsychotics. I don't know I just don't feel good. Sucks! The voices seem to be fading away though. So that much is positive.Friends,
The poster writes that they checked "Drus.com" and found nothing significant in the interactions of the drugs listed except a possible interaction between Cymbalta and trazodone and the 3 atypical antipsychotics.
Be not deceived n thinking that the interactions can not be significant. It is plainly visible in the list on drugs .com that death is a possibility via serotonin syndrome and that there are cns depressants combined that could cause death among all the other adverse consequences that could happen to those that take these drugs in combination.
Here is the link to what the poster wrote that they saw.
Lou
http://www.drugs.com/interactions-check.php?drug_list=2228-0,949-2273,1781-2498,1781-13969,3168-13988,1744-1113
Posted by Lou Pilder on April 27, 2013, at 9:08:29
In reply to Lou's response-nuttinsignif » vbs, posted by Lou Pilder on April 27, 2013, at 8:57:05
> > > Hi VBS did you ask your pharmacist if any interractions with the combo? Phillipa
> >
> > No. I'll call my pharmacist tomorrow. I did check for interactions at drugs.com though. Nothing significant except for *possible* interactions b/w trazodone and Cymbalta and b/w the 3 atypical antipsychotics. I don't know I just don't feel good. Sucks! The voices seem to be fading away though. So that much is positive.
>
> Friends,
> The poster writes that they checked "Drus.com" and found nothing significant in the interactions of the drugs listed except a possible interaction between Cymbalta and trazodone and the 3 atypical antipsychotics.
> Be not deceived n thinking that the interactions can not be significant. It is plainly visible in the list on drugs .com that death is a possibility via serotonin syndrome and that there are cns depressants combined that could cause death among all the other adverse consequences that could happen to those that take these drugs in combination.
> Here is the link to what the poster wrote that they saw.
> Lou
> http://www.drugs.com/interactions-check.php?drug_list=2228-0,949-2273,1781-2498,1781-13969,3168-13988,1744-1113Friends,
Be not deceived. Look at the interactions between Trazodone, Saphris and Invega. These can interact to cause death via heart failure. You see, when these type of drugs are taken in combination, the effects are multiplied.
Let us look at them taken by themselves
Lou
http://www.ehealthme.com/ds/trazodone/death
http://www.ehealhtme.com/ds/saphris/death
http://www.ehealthme.com/ds/invega/death
http://www.ehealthme.com/ds/cymbalta/death
http://www.ehealthme.com/ds/zyprexa/death
Posted by SLS on April 27, 2013, at 9:36:57
In reply to Lou's response-trazsaphrisnvega, posted by Lou Pilder on April 27, 2013, at 9:08:29
> Be not deceived. Look at the interactions between Trazodone, Saphris and Invega. These can interact to cause death via heart failure.
For my edification, can you provide evidence for cause and effect? Thanks.
eHealthMe likes to present numbers without providing guidance for how to interpret them.
Worse - eHealthMe includes in their statistics reports that do NOT come from the FDA. As you can see from the quote taken from the webpage you cited, the vast majority of the reports they use in their statistics come from unspecified studies.
"This is a real world study of Death among people who take Zyprexa. It is created by eHealthMe based on 1,462 reports from FDA. In total 41,631 Zyprexa users are studied."
Be not deceived.
- Scott
Posted by vbs on April 27, 2013, at 10:53:38
In reply to Re: Invega Sustenna and 4 other meds » vbs, posted by SLS on April 27, 2013, at 7:46:31
I spoke with my pharmacist about any interactions b/w my meds. She said there are no major interactions. :-)
Voices are still lingering. They're almost gone. It's much better now than before.
Yeah I'd like to just stop the Zyprexa but I'm afraid of rebound symptoms.
Posted by vbs on April 27, 2013, at 11:06:49
In reply to Lou's response-trazsaphrisnvega, posted by Lou Pilder on April 27, 2013, at 9:08:29
I don't trust ehealthme. I trust my pharmacist. She said there are NO major interactions. I don't recall reading anything about heart failure at drugs.com. And I don't think my pdoc would prescribe these meds if he thought the combo was unsafe.
Posted by SLS on April 27, 2013, at 12:33:12
In reply to Re: Invega Sustenna and 4 other meds » SLS, posted by vbs on April 27, 2013, at 4:58:23
> Apparently it takes time for Invega Sustenna to work. I've only been on it for nine days.
I just wanted to add that antipsychotics take longer to work in schizoid disorders than they do in bipolar disorder mania. It often takes six weeks for them to take full effect in schizophrenia whereas mania can be controlled within hours to a few days. That the voices you hear are substantially muted after only nine days is encouraging.
I hope your improvement continues.
- Scott
Posted by vbs on April 27, 2013, at 12:58:55
In reply to Re: Invega Sustenna and 4 other meds » vbs, posted by SLS on April 27, 2013, at 12:33:12
Yeah the voices are muted. That's a good way to phrase it. Thanks for the encouraging words.
I checked for drug interactions with another pharmacist. She said I was okay except watch for abnormal heart rhythm b/w Saphris & Invega Sustenna. That makes me feel better knowing that two pharmacists said I was okay, no serious interactions.
Posted by SLS on April 27, 2013, at 13:33:13
In reply to Re: Invega Sustenna and 4 other meds » SLS, posted by vbs on April 27, 2013, at 12:58:55
> Yeah the voices are muted. That's a good way to phrase it. Thanks for the encouraging words.
>
> I checked for drug interactions with another pharmacist. She said I was okay except watch for abnormal heart rhythm b/w Saphris & Invega Sustenna. That makes me feel better knowing that two pharmacists said I was okay, no serious interactions.A simple ECG will show you if these drugs are producing a prolongation of the QT interval, a type of arrhythmia. Generally, there is very little concern unless a cardiac conduction anomaly already exists. I have never seen anything in the literature that describes heart-failure as a possible adverse effect of antipsychotics.
- Scott
Posted by Lou Pilder on April 27, 2013, at 16:49:02
In reply to Re: Lou's response-trazsaphrisnvega » Lou Pilder, posted by vbs on April 27, 2013, at 11:06:49
> I don't trust ehealthme. I trust my pharmacist. She said there are NO major interactions. I don't recall reading anything about heart failure at drugs.com. And I don't think my pdoc would prescribe these meds if he thought the combo was unsafe.
vbs and friends,
the heart complications when taking Cymbalta are listed in the following article. One is sudden death.
Lou
http://www.livestrong.com/article/74136-cymbalta-cardiac-complications
Posted by Lou Pilder on April 27, 2013, at 17:30:12
In reply to Lou's response-trazsaphrisnvega, posted by Lou Pilder on April 27, 2013, at 9:08:29
> > > > Hi VBS did you ask your pharmacist if any interractions with the combo? Phillipa
> > >
> > > No. I'll call my pharmacist tomorrow. I did check for interactions at drugs.com though. Nothing significant except for *possible* interactions b/w trazodone and Cymbalta and b/w the 3 atypical antipsychotics. I don't know I just don't feel good. Sucks! The voices seem to be fading away though. So that much is positive.
> >
> > Friends,
> > The poster writes that they checked "Drus.com" and found nothing significant in the interactions of the drugs listed except a possible interaction between Cymbalta and trazodone and the 3 atypical antipsychotics.
> > Be not deceived n thinking that the interactions can not be significant. It is plainly visible in the list on drugs .com that death is a possibility via serotonin syndrome and that there are cns depressants combined that could cause death among all the other adverse consequences that could happen to those that take these drugs in combination.
> > Here is the link to what the poster wrote that they saw.
> > Lou
> > http://www.drugs.com/interactions-check.php?drug_list=2228-0,949-2273,1781-2498,1781-13969,3168-13988,1744-1113
>
> Friends,
> Be not deceived. Look at the interactions between Trazodone, Saphris and Invega. These can interact to cause death via heart failure. You see, when these type of drugs are taken in combination, the effects are multiplied.
> Let us look at them taken by themselves
> Lou
> http://www.ehealthme.com/ds/trazodone/death
> http://www.ehealhtme.com/ds/saphris/death
> http://www.ehealthme.com/ds/invega/death
> http://www.ehealthme.com/ds/cymbalta/death
> http://www.ehealthme.com/ds/zyprexa/deathFriends,
It is written here in another post that the poster did not see anything about heart complications/death in the drugs.com interactions of the 5 drugs in question here.
Now the link here by me in this post shows the interactions of the 5 drugs. Notice that with Trazodon, Saphris/Invega that there is the listing of
A. Irregular heart rhythm
B. prolongation of the QT interval
C. Sudden death from the combination of Invega and Saphris
But it is much more than that. You see, when all 5 drugs are combined, there becomes a dramatic increase of the potential of death. There are deaths from taking a pain pill and then a glass of wine. If you took just the pain pill(opiate} or just the wine, that would not be the same as taking them together.
I am not anti-drug or anti-psychiatry. I am anti-death. And the prohibitions to me here prevent me from responding to the (redacted by respondent)here.
I am requesting that those interested in this thread go to the admin board here and look at the last thread there in relation to what's being allowed to stand here about me, and the tactics being used. If you could, then I think that you could have your eyes opened to how hate is promulgated here that psychologists say could keep readers from overcoming depression and addiction. And then they could become prisoners of the drugs and kill themselves and or others, and even commit mass-murder. My friends, it is your choice as to whom you want to believe. It has been revealed to me that thousands of years ago the scriptures that the Jews use told of these days and The Great Deception. I am prevented from telling you about that here due to the prohibitions to me here by Mr Hsiung.
Lou
Posted by vbs on April 27, 2013, at 17:35:53
In reply to Lou's response-mighfarmasystsez » vbs, posted by Lou Pilder on April 27, 2013, at 16:49:02
Hi Lou, I wasn't aware of Cymbalta causing possible heart complications. Thanks for bringing that to my attention. As they say, knowledge is power.
Posted by vbs on April 27, 2013, at 17:59:28
In reply to Lou's urgent warning-combination of drugs/death, posted by Lou Pilder on April 27, 2013, at 17:30:12
Lou, I know you're trying to help. I am aware of the potential for serious interactions like those that you mentioned. I trust that my treatment team (pharmacist included) knows what they're doing. I have a serious mental illness, schizoaffective disorder w/ major depression. I'm not hearing voices right now and I don't feel depressed. Is the medicine working? In my case, the benefits outweigh the risks. I don't particularly like hearing voices and feeling depressed. I feel good at this moment.
Posted by SLS on April 27, 2013, at 19:18:45
In reply to Re: Lou's response-mighfarmasystsez » Lou Pilder, posted by vbs on April 27, 2013, at 17:35:53
> Hi Lou, I wasn't aware of Cymbalta causing possible heart complications.
What complications are you concerned about?
> Thanks for bringing that to my attention. As they say, knowledge is power.
What sources of information are you relying upon?
- Scott
Posted by Phillipa on April 27, 2013, at 20:33:45
In reply to Re: Lou's urgent warning-combination of drugs/deat » Lou Pilder, posted by vbs on April 27, 2013, at 17:59:28
VBS sorry to take so long to reply. Glad you checked with two pharmacists. I find them a wealth of information. Also have found they will research the meds in question. Isn't there a medical professional in your family also? If so I"m sure they would caution you if they felt there was a problem. Glad the voices are fading. Phillipa
Posted by vbs on April 28, 2013, at 6:36:44
In reply to Re: Invega Sustenna and 4 other meds » vbs, posted by SLS on April 27, 2013, at 19:18:45
SLS, I don't know how reliable the information is but Lou referenced an article on the web: http://www.livestrong.com/article/74136-cymbalta-cardiac-complications
The article says that Cymbalta can cause tachycardia, arrhythmia, and palpitations. Is this not true?
Personally, I'm not particularly concerned about any possible heart complication. I haven't experienced any.
Posted by vbs on April 28, 2013, at 6:47:59
In reply to Re: Lou's urgent warning-combination of drugs/deat » vbs, posted by Phillipa on April 27, 2013, at 20:33:45
Hi Phillipa, yes, there is a medical professional in my family. My father is a doctor and my brother is a dentist. And I haven't asked them about drug interactions. I don't want to worry them.
Yeah the voices are nearly gone. I'm not hearing any right now. They fade in & out. :-)
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