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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 44. This is the beginning of the thread.
Posted by medamorphosis on December 14, 2010, at 13:42:27
Ok, this is becoming ulmost rediculus. Been trying more & more addons the my MAOI (Marplan) but each trials has its own set of problems. So now Ive just stopped amitriptyline Oi strait on Valdoxan (agomelatine). One of the newwer ADs im told. I certainly like the idea behind it. With the m1 & m2 meletonin receptors agonist effects Im hoping it will correct my sleeping patterns and do away with my heypersomnia. Also is a 5-HT2C antagonist Which in turn boosts NE/na & DA (?). Hope this is the big gun I need...
Posted by medamorphosis on December 14, 2010, at 15:17:55
In reply to Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 13:42:27
> Ok, this is becoming ulmost rediculus. Been trying more & more addons the my MAOI (Marplan) but each trials has its own set of problems. So now Ive just stopped amitriptyline Oi strait on Valdoxan (agomelatine). One of the newwer ADs im told. I certainly like the idea behind it. With the m1 & m2 meletonin receptors agonist effects Im hoping it will correct my sleeping patterns and do away with my heypersomnia. Also is a 5-HT2C antagonist Which in turn boosts NE/na & DA (?). Hope this is the big gun I need...
>Well 2hrs ago I took my 1st 25mg. Feel it already! No nausia, realities untouched and yes, my mood has already lightened. :) Slight warm glow to the face and slight blurred vision, yet no hypomania or sedation in the slightest. Well, not yet lol. Fingers crossed!
med
Posted by medamorphosis on December 14, 2010, at 15:24:27
In reply to Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 13:42:27
A decent Wikipedia link: http://en.wikipedia.org/wiki/Agomelatine
Posted by medamorphosis on December 15, 2010, at 0:09:37
In reply to Re: Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 15:24:27
So I went to sleep by 9pm. Its now 6am and I woke 2hrs ago. WOW! Normally I'd be hanging but I feel wide awake. Start of something new?
And any Valdoxan users out there, past or present please share your experiences.med
Posted by SLS on December 15, 2010, at 4:32:25
In reply to Re: Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 15:17:55
Hi.
> Well 2hrs ago I took my 1st 25mg. Feel it already!
Yes. I believe that this is possible. I took my first dose of Valdoxan at bedtime. I woke up feeling significantly better. No placebo here. However, this antidepressant response lasted for no longer than three days. I was surprised that it returned two weeks later. Unfortunately, after another three days, I relapsed and quit taking Valdoxan, perhaps prematurely. I have since added Abilify and am receiving significant from it. I am very seriously thinking about re-trialing Valdoxan, now that Abilify is onboard and the terrain of my brain has changed.
- Scott
Posted by Conundrum on December 15, 2010, at 12:40:02
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by SLS on December 15, 2010, at 4:32:25
Sorry to butt in, sounds like what happened when i tried remeron, it started to work a week and a half later than stopped. 5 HT2C antagonism is great, but I think sometimes you need an increase in serotonin to keep it from pooping out. Perhaps 5 HT1a agonism keeps the dopamine norepinephrine disinhibition going?
> Hi.
>
> > Well 2hrs ago I took my 1st 25mg. Feel it already!
>
> Yes. I believe that this is possible. I took my first dose of Valdoxan at bedtime. I woke up feeling significantly better. No placebo here. However, this antidepressant response lasted for no longer than three days. I was surprised that it returned two weeks later. Unfortunately, after another three days, I relapsed and quit taking Valdoxan, perhaps prematurely. I have since added Abilify and am receiving significant from it. I am very seriously thinking about re-trialing Valdoxan, now that Abilify is onboard and the terrain of my brain has changed.
>
>
> - Scott
>
>
Posted by medamorphosis on December 15, 2010, at 20:19:14
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by SLS on December 15, 2010, at 4:32:25
> Hi.
>
> > Well 2hrs ago I took my 1st 25mg. Feel it already!
>
> Yes. I believe that this is possible. I took my first dose of Valdoxan at bedtime. I woke up feeling significantly better. No placebo here. However, this antidepressant response lasted for no longer than three days. I was surprised that it returned two weeks later. Unfortunately, after another three days, I relapsed and quit taking Valdoxan, perhaps prematurely. I have since added Abilify and am receiving significant from it. I am very seriously thinking about re-trialing Valdoxan, now that Abilify is onboard and the terrain of my brain has changed.
>
>
> - Scott
>
>
Thanks Scott very interesting. Perhapse all it did for you was normalise your sleep and thats all? It is also said that 25mg is NOT actually the reall dose for best theraputic responce, yet many docs stop at 25mg. 50 sounds more like it. Did you go to 50mg?
And personally, if all it does do is normalise my sleep patterns, then thats a big bonus for myself.
I'll keep Abilify in mind too. May I ask, whats you diagnosis(s) and what does the Abilify help with specifically? Thanx.med
Posted by medamorphosis on December 15, 2010, at 20:33:39
In reply to Re: Valdoxan (agomelatine), posted by Conundrum on December 15, 2010, at 12:40:02
> Sorry to butt in, sounds like what happened when i tried remeron, it started to work a week and a half later than stopped. 5 HT2C antagonism is great, but I think sometimes you need an increase in serotonin to keep it from pooping out. Perhaps 5 HT1a agonism keeps the dopamine norepinephrine disinhibition going?
Hey, butt in whenever you like! :)
You got me thinking, esp as theres only so much of an assortment of meds my doc will give me-and rightly so. HOWEVER, one drug available OTC is diphenhydramine, and its said to be a SRI. How specific and how potent I dont know, but i might be a possible candidate in your theory that a serotonin enhancer might keep a 5 HT2C antagonist from poopin out. What ya think?
Posted by medamorphosis on December 15, 2010, at 20:42:35
In reply to Re: Valdoxan (agomelatine) » Conundrum, posted by medamorphosis on December 15, 2010, at 20:33:39
Posted by alchemy on December 15, 2010, at 21:05:50
In reply to Re: Valdoxan (agomelatine), posted by Conundrum on December 15, 2010, at 12:40:02
I tried it for about a month with high hopes (rapid cycling & stuff).
I didn't notice anything. sorry :(But I know it was a miracle for Ron Hill
Posted by SLS on December 15, 2010, at 21:11:28
In reply to Re: Valdoxan (agomelatine) » SLS, posted by medamorphosis on December 15, 2010, at 20:19:14
Hi.
I tried taking Valdoxan at a dosage of 50mg for about a week. I felt somewhat more depressed. This is a point of interest to me as melatonin supplements make me feel the same way.
> I'll keep Abilify in mind too. May I ask, whats you diagnosis(s) and what does the Abilify help with specifically? Thanx.
Abilify is very capable of producing increases in mental energy and motivation. However, in my experience, I found that it may not improve anhedonia as much. Abilify helps me more when I am taking other medications at the same time.
Currently:
Nardil 90mg
nortriptyline 150mg
Lamictal 200mg
Abilify 10mgI see that many people with unipolar depression do well at 2.5 to 5.0 mg. of Abilify. I actually do best at 10 mg. 20mg made me feel somewhat muddy.
- Scott
Posted by medamorphosis on December 15, 2010, at 21:29:30
In reply to Re: Valdoxan (agomelatine), posted by alchemy on December 15, 2010, at 21:05:50
> I tried it for about a month with high hopes (rapid cycling & stuff).
> I didn't notice anything. sorry :(
>
> But I know it was a miracle for Ron HillRapid cycling must be ruff, though thankfull I have no indication of bipolar, not to my knowledge. But who knows..
Is Ron Hill still on here? If you know him maybe youcould ask him to babblemail me? Otherwise no matter. Thanks for ur input!med
Posted by medamorphosis on December 15, 2010, at 21:44:20
In reply to Re: Valdoxan (agomelatine) » Conundrum, posted by medamorphosis on December 15, 2010, at 20:33:39
Hang on hang on. Why am I thinking of diphehydramine, when I have plenty of amnitryptyline left over? Im sure 25 to 50mg would suffice to create the SRI conditions on which your theory is based.
I also still have plenty of trimipramine left. It has much different & more actions inc 5-HT2 antagonism. Lots of other effcts tho http://en.wikipedia.org/wiki/Trimipramine
Im not going to play with all that at once- Im actually trying to get better lol. But its nice to know what ur arsnel is ;) lol
Posted by Phillipa on December 15, 2010, at 21:52:24
In reply to Re: Valdoxan (agomelatine) » alchemy, posted by medamorphosis on December 15, 2010, at 21:29:30
Ron not that long ago posted of his success might want to google his name and babblemail him? Phillipa
Posted by medamorphosis on December 15, 2010, at 22:23:45
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by Phillipa on December 15, 2010, at 21:52:24
> Ron not that long ago posted of his success might want to google his name and babblemail him? Phillipa
Thanks, might do that :)
Posted by Conundrum on December 16, 2010, at 11:51:39
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by medamorphosis on December 15, 2010, at 21:44:20
An example of the important of SRI with 5 HT2 antagonism is Serzone. It is a potent 5 HT2 receptor antagonist even at low doses, but it is not until you get to the higher doses where there is more SRI that it starts to become an effective antidepressant. I don't know what you should add to help with the serotonin, or if it would definitely work. I would talk to your doctor, I don't know anything about what interacts with valdoxan.
Posted by medamorphosis on December 16, 2010, at 15:44:35
In reply to Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 13:42:27
So far so good- well no negatives. Though I have completely lost my appetite. Feels just like my 1st week on buspirone. I'm on a diet of whole milk & fruit, its all I can manage. ATM I dont consider this a negative. I need to loose a little weight. As long as it doesn't get worse I deal with it. Iteresting tho... Any ideas wich mechanism might be causing loss of appetite? Or maybe its a rebound from amitryptyline? Tho I had no particular apetite on that.
med
Posted by medamorphosis on December 16, 2010, at 16:42:57
In reply to Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 13:42:27
NOTE: Im not advacating at all, I just believe in free speach for eductional use only ;)
Anyway, One thing bizzare which happened yesterday is that after a few cannabis joints I was getting closed-eye hallucinations. I NEVER get them with cannabis alone. Melotonin playing a part? Hhmmm...
Posted by Conundrum on December 17, 2010, at 10:39:20
In reply to Re: Valdoxan + appetite, posted by medamorphosis on December 16, 2010, at 15:44:35
Could be the amitriptyline rebound. How long have you been off it?
> So far so good- well no negatives. Though I have completely lost my appetite. Feels just like my 1st week on buspirone. I'm on a diet of whole milk & fruit, its all I can manage. ATM I dont consider this a negative. I need to loose a little weight. As long as it doesn't get worse I deal with it. Iteresting tho... Any ideas wich mechanism might be causing loss of appetite? Or maybe its a rebound from amitryptyline? Tho I had no particular apetite on that.
>
> med
Posted by medamorphosis on December 17, 2010, at 10:57:14
In reply to Re: Valdoxan + appetite, posted by Conundrum on December 17, 2010, at 10:39:20
> Could be the amitriptyline rebound. How long have you been off it?
>
Since last Sunday, 5 days. Yet I never had appetite issues whilst i was on it. So perhapse this is withdrawal more than anythings elso, oh and im stil on liquids.
Posted by ed_uk2010 on December 18, 2010, at 9:06:16
In reply to Over 18s ONLY, posted by medamorphosis on December 16, 2010, at 16:42:57
>Re: Over 18s ONLY
Ya know, I went straight to this post (not sure what that says about me). I thought you were going to tell us something really REALLY bad.
Posted by medamorphosis on December 18, 2010, at 9:16:06
In reply to Re: Over 18s ONLY, posted by ed_uk2010 on December 18, 2010, at 9:06:16
> >Re: Over 18s ONLY
>
> Ya know, I went straight to this post (not sure what that says about me). I thought you were going to tell us something really REALLY bad.HA_HA! Sorry to disappoint ;) Though i could do if you like? Allways wanted to go on a huge robbing spree! :D
Posted by sigismund on December 18, 2010, at 14:54:21
In reply to Re: Over 18s ONLY, posted by ed_uk2010 on December 18, 2010, at 9:06:16
Yes. I had my hopes up too.
Posted by sigismund on December 18, 2010, at 15:00:23
In reply to Re: Over 18s ONLY » ed_uk2010, posted by medamorphosis on December 18, 2010, at 9:16:06
The improved sleep from agomelatine is gone with me, but I stll take it because of the push it gives me.
I cope much better with crappy sleep the day after with it.
I don't know what to do about the sleep thing, so I have decided to go with the flow.
Posted by medamorphosis on December 18, 2010, at 17:57:16
In reply to Re: Over 18s ONLY, posted by sigismund on December 18, 2010, at 15:00:23
> The improved sleep from agomelatine is gone with me, but I stll take it because of the push it gives me.
>
> I cope much better with crappy sleep the day after with it.
>
> I don't know what to do about the sleep thing, so I have decided to go with the flow.I have small stocks of old meds leftover (haven't we all?).
Ive already tried adding trimipramine, a particularly strong 5-HT2 agonist to agomelatine. Too many dreams for me in one night thankyou! But just showing it can be done. No toxic 'interaction' from what I felt. But I easily have bad/vivid dreams. It might be an excellent 5-HT2 agonist combo for some...
med
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