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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 35. This is the beginning of the thread.
Posted by Phillipa on October 22, 2007, at 23:33:28
Deplin is now considered a prescription med and not a supplement good news for treatment resistant depression as it boosts ad's dopamine, norepenephine, serotonin. A bit from the site but suggest you google it four pages long. Phillipa
associated with mood.
Deplin® tablets contain 7.5mg of L-methylfolate
Deplin® is the first medical food product indicated for the distinct nutritional requirements of persons with low plasma and/or low red blood cell folate with particular emphasis for those individuals who have a major depressive disorder that has not fully responded or may not fully respond to antidepressant therapy.
Deplin® is available by prescription only
Posted by d0pamine on October 23, 2007, at 2:04:11
In reply to Now Considered a Prescription Med Good News!!!!!!!, posted by Phillipa on October 22, 2007, at 23:33:28
How is it good news when a seemingly safe and effective otc remedy is locked away from the masses and sole control is handed to the few?
Posted by Squiggles on October 23, 2007, at 10:13:58
In reply to Now Considered a Prescription Med Good News!!!!!!!, posted by Phillipa on October 22, 2007, at 23:33:28
Good news for whom? I looked it up on
Rx and it is a folate nutritional supplement
for people with low leucoplacates or something;
nothing about treatment resistant depression.
That kind of depression is very dangerous, and
introducing a nutritional supplement is ....
well, go figure.Squiggles
Posted by Phillipa on October 23, 2007, at 12:01:06
In reply to Re: Now Considered a Prescription Med Good News!!!, posted by Squiggles on October 23, 2007, at 10:13:58
Squggles did you speciafically google deplin? As it says treatment resistant booster? I went to the official Deplin site . The advantage would be monitoring of a doctor and blood work if folate is deficient and insurance coverage. A a doc monitoring it. I'm sure it's not for everyone but a bonus for those it's indicated for. Phillipa
Posted by tecknohed on October 23, 2007, at 14:24:44
In reply to Re: Now Considered a Prescription Med Good News!!!, posted by d0pamine on October 23, 2007, at 2:04:11
> How is it good news when a seemingly safe and effective otc remedy is locked away from the masses and sole control is handed to the few?
You CAN buy it from online sources, often under another brand name Metafolin. Otherwise, try searching using its non-branded names: L-methylfolate OR L-5-methyl tetrahydrofolate.
Posted by tecknohed on October 23, 2007, at 14:38:51
In reply to Re: Now Considered a Prescription Med Good News!!!, posted by Squiggles on October 23, 2007, at 10:13:58
> Good news for whom? I looked it up on
> Rx and it is a folate nutritional supplement
> for people with low leucoplacates or something;
> nothing about treatment resistant depression.
> That kind of depression is very dangerous, and
> introducing a nutritional supplement is ....
> well, go figure.
>
> SquigglesI take it you're against the use of nutritional supplements for treatment resistant depression?
What if you have trouble converting folic acid/folate into its 'active' form, which is what the site Phillipa refers to happens to lots of people? Few antidepressants would help depression caused by such a deficiency. I would call this 'treatment resistant depression'. At least some pharmacuetical companies are starting to admit that its not all just drug, drugs, drugs.
I suspect micronutrient deficiencies play a HUGE role in 'treatment resistant depressions'.
Just look at lithium! When being treated with lithium you are effectively taking 'mega doses' of a micronutrient!
Not to mention St. John's Wort, which has pulled me out of depression better than any SSRI ever has!
Posted by Squiggles on October 23, 2007, at 15:26:50
In reply to Re: Now Considered a Prescription Med Good News!!! » Squiggles, posted by tecknohed on October 23, 2007, at 14:38:51
Well, i don't know.... i will have to
look up "deplin". Lithium is not a micronutrient;
though it is found in the body in extremely tiny
amounts.Squiggles
Posted by Squiggles on October 23, 2007, at 16:10:57
In reply to Re: Now Considered a Prescription Med Good News!!! » tecknohed, posted by Squiggles on October 23, 2007, at 15:26:50
I looked up L-methylfolate;
I found about 6 articles on PubMed,
one by a well-recognized researcher,
Dr. Stahl. It seems that its efficacy
as found in clinical trials comparing
schizophrenics, depressives against controls,
is based on the theory that folate acid
may be lower in such. And so, this addition
is an enhancement of an already existing
antidepressant. The vitamin B12 is related.
This sounds like a new direction in psychiatry.
That's all i can say.I hope i got that right.
Interesting variation in countries' origin
of research: Britain, US, and Greece.It is approved by the FDA as a supplement to
enhance ADs.Any feedback, would be appreciated. It sounds
fishy to me.
Squiggles
Posted by Phillipa on October 23, 2007, at 17:53:37
In reply to Re: Now Considered a Prescription Med Good News!!! » Squiggles, posted by Squiggles on October 23, 2007, at 16:10:57
Squiggles it's definietly a med to boost antidepressants nothing to do with psychology. I have the info . Trying to figure out how to post it without a confidentiality problem.Phillipa
Posted by tecknohed on October 23, 2007, at 18:32:17
In reply to Re: Now Considered a Prescription Med Good News!!! » tecknohed, posted by Squiggles on October 23, 2007, at 15:26:50
> Well, i don't know.... i will have to
> look up "deplin". Lithium is not a micronutrient;
> though it is found in the body in extremely tiny
> amounts.
>
> SquigglesThink you just contradicted yourself.
:)
Posted by Phillipa on October 23, 2007, at 18:40:55
In reply to Re: Now Considered a Prescription Med Good News!!! » Squiggles, posted by tecknohed on October 23, 2007, at 18:32:17
Squiggles and everyone the link I said I would post. Phillipa
http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=1267
Posted by Squiggles on October 23, 2007, at 18:48:05
In reply to Re: Here's the Link!, posted by Phillipa on October 23, 2007, at 18:40:55
> Squiggles and everyone the link I said I would post. Phillipa
>
>
> http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=1267Well, it can't hurt to try; one advantage would be
that you may be able to lower the dose of a very toxic AD.I am a bit concerned about the massive pharmaceutical banquet, and that it is
only checked by the FDA and approved, not
examined. I may be wrong about that.
There's not much written on it except for the
group working on this new direction.Squiggles
Posted by Phillipa on October 23, 2007, at 19:28:47
In reply to Re: Here's the Link! » Phillipa, posted by Squiggles on October 23, 2007, at 18:48:05
More options now for teatment resistant depression has to be a good thing. Phillipa
Posted by Phillipa on October 24, 2007, at 10:33:17
In reply to Re: Here's the Link! » Squiggles, posted by Phillipa on October 23, 2007, at 19:28:47
Very important . Asked to pass along the info that deplin is a drug not a supplement. Phillipa
Deplin is a DRUG and not a nutrient.
It is not found in natural foodstuffs. Folic acid is a nutrient and is the
natural form of folate available to the body in its diet. Folic acid must
be transformed into L-methylfolate in the liver and muscle tissue
before it can penetrate the brain readily and participate in chemical
there.
Posted by Squiggles on October 24, 2007, at 10:48:45
In reply to Re: Here's the Link!, posted by Phillipa on October 24, 2007, at 10:33:17
> Very important . Asked to pass along the info that deplin is a drug not a supplement. Phillipa
>
>
> Deplin is a DRUG and not a nutrient.
>
> It is not found in natural foodstuffs. Folic acid is a nutrient and is the
> natural form of folate available to the body in its diet. Folic acid must
> be transformed into L-methylfolate in the liver and muscle tissue
> before it can penetrate the brain readily and participate in chemical
> there.
I thought it did not cross the blood-brain barrier; anyway, do you think it's related at
all to what Dr. Preskorn refers to as certain
enzymes which change the metabolism of some
SSRIs? I think that is how he explained the
adverse reaction to Serzone (liver metabolism)
of some people and not others.Squiggles
Posted by tecknohed on October 24, 2007, at 11:55:34
In reply to Re: Here's the Link!, posted by Phillipa on October 24, 2007, at 10:33:17
> Very important . Asked to pass along the info that deplin is a drug not a supplement. Phillipa
>
>
> Deplin is a DRUG and not a nutrient.
>
> It is not found in natural foodstuffs. Folic acid is a nutrient and is the
> natural form of folate available to the body in its diet. Folic acid must
> be transformed into L-methylfolate in the liver and muscle tissue
> before it can penetrate the brain readily and participate in chemical
> there.Not sure about it NOT being a nutrient. Its still Folate wich has been 'activated', which is what happens naurally in the body anyway. You wouldn't call serotonin a drug, which is made from tryptophan, a naturally occuring nutrient, would you?
Don't worry though, I'm NOT disagreeing with YOU, just with whoever asked you to pass the info on. And its just an oppinion, not an argument.
:)teck
Posted by Phillipa on October 24, 2007, at 12:37:34
In reply to Re: Here's the Link! » Phillipa, posted by tecknohed on October 24, 2007, at 11:55:34
Tech I know no argument at all. Now it's up to the pass along person to pick it up. I should clarify that it is not a blocked person just someone I know. Love Jan
Posted by Phillipa on October 24, 2007, at 19:05:26
In reply to Re: Here's the Link! » Phillipa, posted by Squiggles on October 24, 2007, at 10:48:45
Squiggles I have no idea someone sent me the info that is very smart. Phillipa
Posted by KayeBaby on October 24, 2007, at 22:11:41
In reply to Re: Now Considered a Prescription Med Good News!!! » Squiggles, posted by Phillipa on October 23, 2007, at 17:53:37
I can confirm that my depression is gone since I started it. It coincided with my 6th week on 9mg Emsam so it could be coincidental but My energy levels have improved remarkably and I have been on EMSAM at some level since early April and have never gotten that effect from it.
I felt the boost in energy and motivation from the first day.
Kaye
Posted by Phillipa on October 24, 2007, at 22:18:52
In reply to Re: Now Considered a Prescription Med Good News!!!, posted by KayeBaby on October 24, 2007, at 22:11:41
Kaye is it expensive? May ask for it next time see my pdoc. What are the side effects? Phillipa
Posted by tecknohed on October 25, 2007, at 4:20:48
In reply to Re: Now Considered a Prescription Med Good News!!!, posted by KayeBaby on October 24, 2007, at 22:11:41
> I can confirm that my depression is gone since I started it. It coincided with my 6th week on 9mg Emsam so it could be coincidental but My energy levels have improved remarkably and I have been on EMSAM at some level since early April and have never gotten that effect from it.
>
> I felt the boost in energy and motivation from the first day.
>
> KayeThats great! I thought there must be something to it! Why else would 'Deplin' be prescription only?
Buy the way, are you actually taking brand name 'Deplin' or are you taking another brand/non-branded form of L-methylfolate (ie.Metafolin)? And what dose are you on?Thanx.
Posted by KayeBaby on October 26, 2007, at 0:11:03
In reply to Re: Now Considered a Prescription Med Good News!!! » KayeBaby, posted by tecknohed on October 25, 2007, at 4:20:48
I started off with Deplin for about two weeks. It has a whopping 7.5mg od l-methylfolate.
I am now taking 3.2 mg of Metafolin by Source Naturals is also l-methylfolate.
I had a little bit of trouble finding it but it was only 10 bucks for a bottle of 60 800mcg. I got two to hold me over till my insurance kicks in in November.
Kaye
Posted by Zyprexa on October 26, 2007, at 14:55:59
In reply to Re: Now Considered a Prescription Med Good News!!!, posted by Squiggles on October 23, 2007, at 10:13:58
My doctor prescribed it for me, to raise my folate and lower homocysine. She said it was also an anti-depressant. I never took it because no one sold it and was not covered by insurance, besided B-vitamins are cheep, like folic acid, so I'm trying that first.
Posted by Ron Hill on October 26, 2007, at 20:38:40
In reply to Now Considered a Prescription Med Good News!!!!!!!, posted by Phillipa on October 22, 2007, at 23:33:28
Note: I posted this to a thread above, but it looks like Dr Bob is (or was) redirecting the thread to PB-Alt. At any rate, I will repost it here in case it disappears above:
------
Kaye,I've been taking Deplin (L-methylfolate) for the past five days and, so far I am enjoying a remarkable benefit in the tx of my bipolar depressive phase. It has completely eliminated my depression.
I am currently taking 15 mg/day.
Will it last? Time will tell. But in the meantime, I'm enjoying life without depression.
What is your response to Deplin?
For those reading this post, here is the URL for the Deplin home page:
http://www.deplin.com/
Click through all the links.-- Ron
Bipolar II with ultra rapid cycling (15 day cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)
600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day Nardil
15 mg/day Deplin
Posted by Ron Hill on October 26, 2007, at 20:57:12
In reply to Re: Now Considered a Prescription Med Good News!!! » KayeBaby, posted by Phillipa on October 24, 2007, at 22:18:52
Jan,
> Kaye is it expensive?
My pharmacy charges my insurance company $54 for thirty 7.5 mg tablets of Deplin. So, it is very inexpensive, compared to other meds. For example, my insurance company pays more than $1,000 per month for my other four meds.
-- Ron
Bipolar II with ultra rapid cycling (15 day cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)
600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day Nardil
15 mg/day Deplin
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Dr. Bob is Robert Hsiung, MD,
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