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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on March 3, 2006, at 9:31:44
In reply to Re: 150mg » linkadge, posted by wildcard11 on March 3, 2006, at 8:27:06
I just find that hard to believe. How long before you went onto another antidepressant ? Don't mean to be a dweeb, but I'd just have to see it to believe it.
Effexor is so addicting for some people that they have to start counting the pelets in the 37.5mg capsules.Linkadge
Posted by linkadge on March 3, 2006, at 9:33:02
In reply to oh » wildcard11, posted by wildcard11 on March 3, 2006, at 8:36:18
Thats still very suprising. Not sying its not possable, but just very suprising.
Linkadge
Posted by Chairman_MAO on March 3, 2006, at 9:49:05
In reply to Re: oh » wildcard11, posted by linkadge on March 3, 2006, at 9:33:02
Many people do not get withdrawal symptoms. I feel a lot of it has to do with the perceived psychological need for the medication.
Posted by linkadge on March 3, 2006, at 12:23:12
In reply to Re: oh » linkadge, posted by Chairman_MAO on March 3, 2006, at 9:49:05
Yes, but a lot of people do have withdrawl symptoms. I would like to say that it was all in my mind, but brain the brain zaps were hard to chalk up to mindset.
I bet you that if, during the withdrawl, you gave me a toss up between a real effexor, and a placebo, I'd be able to tell which one you gave me based on which one one actually relieved withdrawl symtpoms.
Linkadge
Posted by Chairman_MAO on March 3, 2006, at 13:54:32
In reply to Re: oh » Chairman_MAO, posted by linkadge on March 3, 2006, at 12:23:12
Oh, I agree with you. I have suffered through that.
The fact remains that experiments show that some morphine addicts given IV injections of saline when begging for morphine promptly nodded out and went to sleep. They had clinically significant opioid withdrawal symptoms before the saline injections.
This was done in the 1920s. You will never see research like this ever again because it is a universal fact among medical ignoramuses that drug addiction/dependence is solely a property of the drug.
Oh, by the way, SSRIs do not induce physical dependence! Hahahhha! Don't you love this "science"?!?
Posted by Chairman_MAO on March 3, 2006, at 14:02:26
In reply to Re: 150mg » wildcard11, posted by linkadge on March 3, 2006, at 9:31:44
d-amphetamine attenuates SSRI/SNRI withdrawal symptoms. Don't ask me why, but 10-30mg will completely ameliorate the brain zaps, etc. Insofar as being therapeutic beyond that, that's a toss up.
Posted by zeugma on March 3, 2006, at 15:23:18
In reply to Re: Yes » zeugma, posted by Chairman_MAO on March 2, 2006, at 23:18:15
It is a weak 5th1a partial agonist with some other properties. It should be labelled as a REM sleep control drug, if anything.
or did I miss your point >>
no, that is my point.
i take it simply to control my REM sleep until the more long acting REM suppressant (nortriptyline) kicks in. if it did not have this property, I would not take it.
-z
Posted by ed_uk on March 3, 2006, at 16:03:56
In reply to Re: The Truth Do SSRI's and SSNRI's Work For Anyon » yxibow, posted by Chairman_MAO on March 1, 2006, at 10:32:38
Chair,
I would definitely rather be on morphine than Zyprexa. The side effects of morphine are less disturbing. I would treat the constipation with a combination of laxatives. Dopamine antagonists do not agree with me.
Ed
Posted by linkadge on March 3, 2006, at 16:12:11
In reply to Re: oh » linkadge, posted by Chairman_MAO on March 3, 2006, at 13:54:32
Wish I could believe your theory.
Sounds to me like you are going through stimulant withdrawl ? :)Linkadge
Posted by linkadge on March 3, 2006, at 16:13:48
In reply to Re: The Truth Do SSRI's and SSNRI's Work For Anyon » Chairman_MAO, posted by ed_uk on March 3, 2006, at 16:03:56
Dopamine antagonists do not agree with dopamine.
Linkadge
Posted by ed_uk on March 3, 2006, at 16:34:24
In reply to Re: Yes » Chairman_MAO, posted by zeugma on March 2, 2006, at 21:59:11
Z,
You've suffered 'brain zaps'?
And on the subject of SSRIs......
For me, SSRIs reduce the number of thoughts coming into my head. They create an almost serene detachment from the reality of my life. They numb the pain of negative emotions. They allow me to ignore thoughts that I don't want to have (OCD etc). They reduce empathy and motivation. Time passes by unnoticed. Things never seem to get done. Everything gets left until the last minute. I dropped out of university.........but at least I'm calm :) Not quite happy, but I do at least feel pleasant. I take 80mg citalopram (Celexa). I do find it 'anxiolytic' - but at a cost.
Kind regards
Ed
Posted by ed_uk on March 3, 2006, at 16:36:35
In reply to Re: oh » Chairman_MAO, posted by linkadge on March 3, 2006, at 16:12:11
APs make me feel dreadful, just awful. I feel good on codeine, pleasant, cheerful, friendly, warm......
Ed
Posted by ed_uk on March 3, 2006, at 16:46:05
In reply to Re: 150mg » wildcard11, posted by linkadge on March 3, 2006, at 9:31:44
Hi Link
I quit Effexor XR 150mg without tapering. I definitely suffered some withdrawal symptoms, but nothing severe. I guess I was lucky :)
Ed
Posted by zeugma on March 3, 2006, at 16:56:32
In reply to Re: Yes » zeugma, posted by ed_uk on March 3, 2006, at 16:34:24
> Z,
>
> You've suffered 'brain zaps'?yes, it's an electrical feeling. When i started getting them (at sleep induction) I thought it was because I was sleeping too close to an electrical outlet, and started sleeping with my head at the foot of the bed. (!) of course this made no difference. and NB i was not on any drugs whatsoever.
>
> And on the subject of SSRIs......
>
> For me, SSRIs reduce the number of thoughts coming into my head. They create an almost serene detachment from the reality of my life. They numb the pain of negative emotions. They allow me to ignore thoughts that I don't want to have (OCD etc). They reduce empathy and motivation. Time passes by unnoticed. Things never seem to get done. Everything gets left until the last minute. I dropped out of university.........but at least I'm calm :) Not quite happy, but I do at least feel pleasant. I take 80mg citalopram (Celexa). I do find it 'anxiolytic' - but at a cost.
>I think that is anxiolysis. TCA's, in my opinion, are less anxiolytic, less numbing, more physical side effects (dry mouth, and cardiac abnormalities- to which tolerance often develops).
-z
> Kind regards
>
> Ed
Posted by ed_uk on March 3, 2006, at 17:52:20
In reply to Re: Yes » ed_uk, posted by zeugma on March 3, 2006, at 16:56:32
Hi Z :)
>yes, it's an electrical feeling. When i started getting them (at sleep induction) I thought it was because I was sleeping too close to an electrical outlet, and started sleeping with my head at the foot of the bed. (!) of course this made no difference. and NB i was not on any drugs whatsoever.
Do you think your brain zaps are related to those experienced during SRI withdrawal?
>I think that is anxiolysis.
Me too. In terms of side effects, SSRIs are more insidious than TCAs (for me).
Ed
Posted by zeugma on March 3, 2006, at 18:07:08
In reply to Re: Yes » zeugma, posted by ed_uk on March 3, 2006, at 17:52:20
> Hi Z :)
>
> >yes, it's an electrical feeling. When i started getting them (at sleep induction) I thought it was because I was sleeping too close to an electrical outlet, and started sleeping with my head at the foot of the bed. (!) of course this made no difference. and NB i was not on any drugs whatsoever.
>
> Do you think your brain zaps are related to those experienced during SRI withdrawal?
>
It could be. I think it's a result of the serotonin and norepinephrine systems being too weak and the cholinergic system overpowering it. When people wothdraw from an SSRI the serotonin system is depleted, and they enter REM prematurely, experiencing those 'zap' sensations from cholinergic hypersensitivity, which results from the sudden aminergic weakness.
> >I think that is anxiolysis.
>
> Me too. In terms of side effects, SSRIs are more insidious than TCAs (for me).
>I agree. The TCA side effects are apparent from the beginning, and usually recede with time.
-z
> Ed
Posted by Jakeman on March 3, 2006, at 19:33:19
In reply to Re: The Truth Do SSRI's and SSNRI's Work For Anyon, posted by linkadge on February 27, 2006, at 15:09:45
Link,
While I don't entirely agree with your argument against SSRI's I thought I'd throw in a historical anecdote. In the mid 19th century a common treatment for depression was a pill which contained mercury. Abraham Lincoln took them for several years until the adverse side effects became too debilitating.
http://faculty.washington.edu/chudler/linc.html
warm regards, ~Jake
Posted by Jakeman on March 3, 2006, at 20:18:58
In reply to Re: The Truth Do SSRI's and SSNRI's Work For Anyon » yxibow, posted by Chairman_MAO on March 1, 2006, at 10:32:38
Chairman,
I enjoy reading your posts regarding depression and the use of opiods. I tend to agree with the thrust of your arguments. My main question though is how do you obtain these? How do you get a prescription for buprenorphine? From my experience in the US, many doctors are even skittish about prescribing Valium.
warm regards ~Jake
> Why not do a search on medline for opioids in depression, especially buprenorphine? There are plenty of studies documenting the efficacy of psychostimulants for depression, especially in the most debilitating cases (post-stroke, HIV, etc).
>
> Why would it be malpractice to treat depression with an opioid?
Posted by linkadge on March 3, 2006, at 21:17:04
In reply to Re: 150mg » linkadge, posted by ed_uk on March 3, 2006, at 16:46:05
How long was it though, until you went on a new medication ??
Linkadge
Posted by linkadge on March 3, 2006, at 21:20:50
In reply to Re: The Truth Do SSRI's and SSNRI's Work For Anyon » linkadge, posted by Jakeman on March 3, 2006, at 19:33:19
Thats common. The current generation marvels at its present, and laughs at its past.
I hope to live long enough to see an altered conscenious on the role of SSRI's in psychiatry.
Linkadge
Posted by linkadge on March 3, 2006, at 21:23:01
In reply to Re: The Truth Do SSRI's and SSNRI's Work For Anyon » Chairman_MAO, posted by Jakeman on March 3, 2006, at 20:18:58
I havn't taken a SSRI in almost a year now. I still get brain zaps not too unregularly. I usually wake up in a paniced state and have to move my eyes around for a while for it to subside.
Linkadge
Posted by Chairman_MAO on March 3, 2006, at 22:01:43
In reply to Re: oh » Chairman_MAO, posted by linkadge on March 3, 2006, at 16:12:11
Heh. Nope, I actually often take less than prescribed because it barely works, and sometimes I like to be able to eat a full meal.
This isn't really "my theory". I cannot think of what other conclusion to draw from the things I have read, people I have spoken with, and experiences I have had.
Have you ever read anything by Stanton Peele? www.peele.net
Or Thomas Szasz?
www.szasz.com
Posted by Phillipa on March 3, 2006, at 22:40:02
In reply to Re: oh » linkadge, posted by Chairman_MAO on March 3, 2006, at 22:01:43
So what about if you start an SSRI and have absolutely no side effects from it does this mean that if you stick with it and increase you dose it will work or does it mean it won't. Not taking any more after this one or anything for depression. I will just take my valium. And for the record I was on cymbalta 60mg for over three months last year did nothing for depression but did get rid of aches and pains and no start up effects and I just stopped it with no withdrawal either.No brain zaps no nothing. Fondly, Phillipa ps am I the minority or the majority Hummmmmm
Posted by musky on March 3, 2006, at 23:59:34
In reply to Re: Yes » zeugma, posted by ed_uk on March 3, 2006, at 16:34:24
These are all the same drug.. in other words they all block what is SUPPOSED to happen in the brain.
That is scary.
Ive been on Remeron for just about 3yrs and I have never felt good on it. I believe that cognitive therapy and belief of your self and self love is all that you need to overcome issues in life..
These drugs just mask the pain... they dont get at the root of the problem.. That is the issue here.
Ask these doctors how come they dont do blood tests for serontonin levels that they say are supposedly low in depressed people??? just like you would test ones iron levels or cholesterol levels.
I work in a research lab and we study how cells interact and boy you would be really scared if you only knew what antidepressants do to the brains neurotransmitters... It is not right.
Its all about money and a quick fix society.
To me I would rather cry and be depressed and FEEL things than be numbed out. Sure you are not crying or spiraling on these drugs , but that is just my point, you are not ANYTHING. but numb.
WE are human beings for God's sake and need to go through emotions... I dont care how bad it gets for me I will get off my Remeron and get back to my normal brain again.
I ncever ever had weird thoughts go through my brain and frightening fantasies until I started REmeron. THank God I found an acupuncturist who is helping me get off this.. It really works!!! I suggest this to anyone out there who wants to get of medication... There is more than one way to skin a cat so to speak!!!Musky
Posted by yxibow on March 4, 2006, at 0:38:25
In reply to Re: To Linkadge » deniseuk, posted by linkadge on March 1, 2006, at 16:00:02
> But define "antidepressants work". If by work you mean taking a drug produces some very favorable short term effects, then perhaps they do.
>
> But if by work, you mean that the drug gets to the root of the problem, and produces a sustainable, consistant, and dependable relief from the depressive illness, then I'd disagree.You have hit on at least partially a point which I will continue -- the brain... if you are going to believe the biochemical model of neuropsychiatric illness (I prefer to call them than then "mental illness" which tends to have a perjorative sense) then I will continue.
The brain is an ever changing device. I have OCD, which I will have for the rest of my lifetime, due to no fault of anybody but genetics. I have anxiety, and depression due to the same. There will always be ups and downs. So essentially, you're aiming at a moving target.
It is no suprise that a particular drug will work for a particular period of time, because of this moving target. Also over the course of taking the drug, neurons and the like are in a constant, but slow change and flux.
There is no drug that, for the majority of people will "produce.. a sustainable, consistant, and dependable relief", short of possibly those with mild dysthmia or just random good luck.
Short of brain surgery, there is no "getting to the root of the problem" because of this moving target. You can get a good... sometimes even great approximation, but nothing is going to be 100%. Nothing is ever guaranteed in life. Life is for living, and sometimes things suck. Things suck for me horribly now. Things probably suck for a number of people on here horribly. Then discouragement sets in, and trials of drugs are not given long enough time periods. And again, the brain is still a moving target, just like any other part of the body.
So do SSRIs work ? They work for what they are intended for -- relief from depression and anxiety with the informed consent and predisposed knowledge that they, just like any other antidepressant or anxiolytic, could eventually not work at some point.
I think that, if anything, is the root of the matter.
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Dr. Bob is Robert Hsiung, MD,
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