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Dr. Bob is Robert Hsiung, MD,
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Posted by HADD Enough on February 2, 2003, at 17:54:36
In reply to Re: Started Strattera Yesterday To: not enough, posted by HADD Enough on February 2, 2003, at 17:50:53
Posted by HADD Enough on February 2, 2003, at 18:02:19
In reply to Re: Started Strattera Yesterday Woo-Hoo! » HADD Enough, posted by SLynn on February 2, 2003, at 12:35:18
> Hello...
>
> I am so glad that the Strattera is working for you! I am thrilled so far with this new ADD medication myself.
>
> My son (he is 9) started it yesterday. He weighs 65 pounds and they started him on 18 mg...he is to take it for 4 days then increase to 25mg. He was pretty tired all day, but he was not near as "figity". He seemed pretty alert, but the tiredness really got to him. However, he had "tics" on the stimulants and they are now stopping! I am so relieved. Also, he did not get sick...which from what I have read, is a sign of an allergic reaction. They say that the Strattera takes time, so if you are feeling this much better already, just think how you will feel after the next 7 days or so. Also, the "spaciness" that you are feeling seems to be pretty normal the first few days (from everything that I have read...my son is doing the same thing). How did you sleep while on the Strattera compared to the stimulants? My son fell asleep on the floor at 8:30 last night and I had to get him up at 9:45 this morning. I could not believe it! Usually, I cannot get him to go to sleep or sleep peacefully all night. He had the best sleep last night than he has had in years! Please keep us all posted on your progress...this medication is so new that is nice to read about what others are going through. I am so glad to get my son off of stimulants (he has been on them for 3 years)...they have really messed him up. I am praying this new drug will work for everyone out there who is sensitive to the stimulant medications. Congratulations and keep us informed!!!
>
> SLynn
>Thanks for your kind words. I am really happy for you and your son and I hope he continues to do well!
I fell asleep easily last night at about midnight, but I woke up at around 5 AM...early for me, but I didn't feel as though I didn't get enough sleep. I'll see how this goes as I progress.
Cheers,
Bill
Posted by SLynn on February 2, 2003, at 20:30:55
In reply to Re: Started Strattera Yesterday Woo-Hoo! » SLynn, posted by not exactly on February 2, 2003, at 13:34:49
> How recently did your son discontinue stimulant medication? The tiredness may be due to stimulant withdrawal rather than a Strattera s/e.
>
> - Bob
>
Hi Bob...He just went off of the stimulant yesterday, so I know that the tiredness is due to the stimulant withdrawal. So far so good with Strattera side effects...have not seen any!
SLynn
Posted by dancingdp on February 5, 2003, at 18:48:24
In reply to Straterra approval., posted by scoper on December 28, 2002, at 2:19:34
Is this site working now? TEST
Posted by fairnymph on February 5, 2003, at 22:15:10
In reply to Re: is strattera the same thing as reboxetine?? » not exactly, posted by Phil on February 2, 2003, at 16:25:35
I found reboxetine very effective for depression, stimulating, and free of side effects. It didn't help with my anxiety/OCD, but it was a fantastic med otherwise, one of the best I've tried (and I've tried half a dozen).
> I should hope so, Reboxetine was a big flop with, I think, everyone on this site who tried it.
Posted by Cindylou on February 7, 2003, at 7:13:57
In reply to Re: Started Strattera Yesterday Woo-Hoo! » not exactly, posted by SLynn on February 2, 2003, at 20:30:55
I posted earlier about severe sedation I experienced my first day on Straterra (I took 25 mg.) The sedation set in about 5 hours after taking it. My pdoc wants me to try it at night, but I haven't tried it since that first day.
I'm very curious to know if anyone else has experienced this effect, and/or has any insights or suggestions. I greatly appreciate any responses!
Thanks,
Cindy
Posted by dancingdp on February 7, 2003, at 9:27:03
In reply to Anybody else sedated on Straterra? Please respond, posted by Cindylou on February 7, 2003, at 7:13:57
> I posted earlier about severe sedation I experienced my first day on Straterra (I took 25 mg.) The sedation set in about 5 hours after taking it. My pdoc wants me to try it at night, but I haven't tried it since that first day.
>
> I'm very curious to know if anyone else has experienced this effect, and/or has any insights or suggestions. I greatly appreciate any responses!
>
> Thanks,
> CindyHi Cindy,
My son who is 10 is on Strattera and has not been tired at all. My suggestion to you go to lower the dose and work your way up gradually. I have a lot of experience with meds and it sound like you started off on too high a dose. You must be sensitive to meds anyway. My suggestion is that you start with 18 mg. I can't believe these doctors that are not more cautious about meds especially a NEW one like strattera. Please TELL your dictor that you would like to lower the dose and slowly work your way up after 4 days on 18 mg. You have to be your own doctor sometimes because doctors so not have all the answers. Good luck and let me know how it goes.
dancin
Posted by mshyper on February 7, 2003, at 10:32:31
In reply to Re: Anybody else sedated on Straterra? Please respond, posted by dancingdp on February 7, 2003, at 9:27:05
My doc started me on 18mg nine days ago. No sedation until day 6, ended day 8, other assorted side effects, none severe, all passed away pretty quickly.
Today is day 10, first day on 40 mg. Boy what a trip. I've had rolling symptoms, overly sensitive fingertips (I type) crawly feelings. It triggered a hypoglycemic episode this morning. All happened in the first 1.5 hours after I took the 40mg. I think it's just from the increase. Will see if it's better tomorrow morning. I also have to mention that I was taking the 18mg with breakfast, and this morning I took it almost half an hour before I got to eat. This could have been the problem. Won't take the med again unless I'm eating with it!
Otherwise, it's helping the major disorganization, focus, frustration problems greatly. I can actually sit down at night when I get home from work and read entire chapters in a book. It used to be one sentence and I was distracted already. By the way, I am a 39-yr old adult female.
Good luck with your course of dosage.
Posted by sjb on February 7, 2003, at 11:49:16
In reply to Anybody else sedated on Straterra? Please respond, posted by Cindylou on February 7, 2003, at 7:13:57
I certainly did and stopped it after 6 days. Still oversleeping and overeating. Does anyone know what that half life is?
Posted by not exactly on February 7, 2003, at 13:00:44
In reply to Re: Anybody else sedated on Straterra? Please respond, posted by sjb on February 7, 2003, at 11:49:16
> Does anyone know what that half life is?
short answer: typically 5 hours, but can be as much as 24 hours
long answer, from the official "prescribing information" document:
Human Pharmacokinetics
Atomoxetine is well-absorbed after oral administration and is minimally affected by food. It is eliminated primarily by oxidative metabolism through the cytochrome P450 2D6 (CYP2D6) enzymatic pathway and subsequent glucuronidation. Atomoxetine has a half-life of about 5 hours. A fraction of the population (about 7% of Caucasians and 2% of African Americans) are poor metabolizers (PMs) of CYP2D6 metabolized drugs. These individuals have reduced activity in this pathway resulting in 10-fold higher AUCs, 5-fold higher peak plasma concentrations, and slower elimination (plasma half-life of about 24 hours) of atomoxetine compared with people with normal activity [extensive metabolizers (EMs)]. Drugs that inhibit CYP2D6, such as fluoxetine, paroxetine, and quinidine, cause similar increases in exposure.[the complete document can be downloaded from http://pi.lilly.com/us/strattera-pi.pdf]
- Bob
Posted by Cindylou on February 7, 2003, at 13:05:04
In reply to Re: Anybody else sedated on Straterra? Please respond, posted by dancingdp on February 7, 2003, at 9:27:03
Thanks everyone for your responses! Dancin, thanks for the suggestion of taking a lower dose. My pdoc is hard to get into, and hard to get in touch with (I am looking for a new one, obviously!) I wonder if, in the meantime, I could just open up the capsule and dump out half?
Thanks again,
cindy
Posted by Cindylou on February 7, 2003, at 13:09:43
In reply to Re: Anybody else sedated on Straterra? Please respond, posted by Cindylou on February 7, 2003, at 13:05:04
I just got an answer on another thread about dumping out the capsule. (Sounds like it's worth a try!)
Thanks again to everyone.
cindy> Thanks everyone for your responses! Dancin, thanks for the suggestion of taking a lower dose. My pdoc is hard to get into, and hard to get in touch with (I am looking for a new one, obviously!) I wonder if, in the meantime, I could just open up the capsule and dump out half?
>
> Thanks again,
> cindy
Posted by HADD Enough on February 7, 2003, at 15:02:44
In reply to Straterra approval., posted by scoper on December 28, 2002, at 2:19:34
I'm now at 60mg/day and still doing great! The side effects I've had so far (upset stomach, constipation) are minor and disappear after a couple of days. They came back for a little bit when I upped the dosage from 40 to 60mg, but I suspect that they will diminsh in time. I saw my pdoc yesterday and told him how much better my concentration, focus and mood have been and discussed my major concern...namely that the drug's effectiveness will diminish over time. He indicated to me that from the clinical trials, and from anecdotal evidence he has heard from his colleagues that the drug's action tended to get better over time (6 months) rather than diminsh. All I know is that, for me, this continues to be a miracle drug!
I'm working with my pdoc to tweak the dosage until I get maximum benefits at minimum dosage. He told me that Lilly has modified their max dosage recommendations from 100mg/day for adults to 80 mg/day. My pdoc said that I could remain at 60mg/day or try to go to 80 when I feel ready. I'm going to stay at 60 for a couple of weeks, and then try 80. If there is no marked difference, I'll probably go back to 60 and settle there, but if 80 is better then I'll stay at 80.
I'll update again in a week or earlier if there is anything else major to report.
Cheers,
HADD Enough
Posted by bennett on February 7, 2003, at 15:30:55
In reply to Re: Anybody else sedated on Straterra? Please resp » dancingdp, posted by mshyper on February 7, 2003, at 10:32:31
Sedation? Oh yes. Only with food? Oh yes!
2nd day - 5 hours after taking 18 mg – middle of the afternoon, I had to lay down – two hours later I woke up still tired
I’ve experienced this off and on since then – and it doesn’t seem to be related to lack of sleep.
High side of this is that I’m weaning myself off of Ambien because I don’t seem to need as much as I used to to get to sleep – and I’m hoping I can get by with out it. By 11-11:30 I’m pretty tired and ready for bed – that’s very unusual for me. 2-3 AM has been my normal “bed time” ever since I had a choice in such things.
Dizziness (if I smoke a cigarette) and sedation are the two side effects I’ve experienced the most so far.
The stimulants I’ve taken in the past had a similar sedative effect. Ritalin and Dexedrine calmed me down so much, I would sometime fall asleep in the afternoon. But by night time I was on a roll and had to knock myself out to get to sleep.But I’m very happy to say that the strattera finally started to help with focus and ADD sx.
I nursed the dose from 18 mg/day, to 18am/18pm with no positive effects. It wasn’t until I took 2 -18 mg caps on the morning of the 8th day that I noted some very positive effects. And on day 9, when I moved both AM and PM doses to 36 mg (I only have 18 mg caps) I began to see results very similar to when I used to take stimulants.
I had to get off Dexedrine about two years ago and went on wellbutrin.
The welbutrin helped in a sideways kind of way by stabilizing my mood so I was able to be quiet enough to attend better but it didn’t help the focus at all. I had to leave my job as a result of this shift in medication – I’d moved into administrative duties that my un-medicated ADD self was entirely unsuited for.I’m on day 12 now, and very pleased with the Rx as far as some ADD sx are concerned. I’ve started finishing old projects (the kind that require reading lists and numbers that I'm not particluarly interested in - but that I really need to get done) that have been sitting around forever.
Yesterday, I found myself going through my running 2 year old to-do list updating it to the present. Without Rx. I cannot get myself to look back at the undone items in a list without getting sidetracked and not getting back to what I was in the middle of when I started.
However, if I were still working in the office I used to work in, the side effects I’ve experienced so far probably would have precluded my staying with it.For instance, this morning I took the dose 1/2 hour before breakfast and an hour later was so nauseous and dizzy that I had to lie down. I spent the next hour and a half on the couch trying to stay centered and quiet till it passed.
Then, as suddenly as the nausea and dizziness came on –it was gone – and I felt fine. I opened my eyes, got up and started working. Fortunately I was at home during all of this.
I won’t take this without food again.
Well, that’s my story so far.My sweetie is coming to visit this weekend and I’ll get to see if the socially interactive sx. have improved. I still talk a lot, but I seem not to interrupt as much. In any event, she’ll let me know since she has seen them at their worst (and their best) over the years.
We’ll be at a festival with lots of people and booths screaming for my attention. If I find I can keep a conversation going with her while we’re walking along – without stopping mid-sentence to talk to someone else or getting totally distracted by something I see … ...
She’ll let me know how this stuff is working….
By the way I'm a 61 yr old male diagnosed ADD in 1992.
thanks,
bennett
Posted by harper on February 7, 2003, at 18:30:16
In reply to Straterra approval., posted by scoper on December 28, 2002, at 2:19:34
My 13 year old daughter has been on 40 mg for the last month. The ADD is much better and she's had no side affects except for sleepiness and an upset stomach the first couple of days. The only problem now is her terrible and increasing moodiness.
Even though I think puberty has something to do with the moodiness, I think she needs an antidepressant along with the Strattera.What antidepressants are others taking with this med? Since this is a new med, her doctor doesn't have any experience with this one (even though he is a big shot at NIMH in child psychiatry!), I want to give him suggestions.
I understand some people are on Wellbutrin with this med. How much and how is it working?
Please respond.
Posted by ShelliR on February 7, 2003, at 19:31:32
In reply to Straterra , posted by harper on February 7, 2003, at 18:30:16
Posted by Cindylou on February 7, 2003, at 21:06:10
In reply to Straterra , posted by harper on February 7, 2003, at 18:30:16
Hi Harper,
I noticed in an earlier post that a teenager on Strattera also had increased moodiness ... it's so hard to tell with all those hormones raging what is causing what.I am taking Lexapro, and so far it is the only antidepressant I've been able to tolerate. My pdoc said the combo of Lexapro and Strattera is fine. (As for my experience, I have only taken Strattera for one day. I was extremely sedated and haven't had the guts to try it again. I am quite confident that the sedation didn't have anything to do with the combo of the meds, however, since I am very med-sensitive and I react strongly to medications across the board.)
Lexapro is an SSRI, like Prozac, but has much fewer side effects. It's quite new, so the drawback is that it's not as "tried and true" as Prozac.
Best of luck to you and your daughter. I had a tough time when I was 13 ... my heart goes out to her and to you!
cindy.
> My 13 year old daughter has been on 40 mg for the last month. The ADD is much better and she's had no side affects except for sleepiness and an upset stomach the first couple of days. The only problem now is her terrible and increasing moodiness.
>
> Even though I think puberty has something to do with the moodiness, I think she needs an antidepressant along with the Strattera.What antidepressants are others taking with this med? Since this is a new med, her doctor doesn't have any experience with this one (even though he is a big shot at NIMH in child psychiatry!), I want to give him suggestions.
> I understand some people are on Wellbutrin with this med. How much and how is it working?
> Please respond.
Posted by mom2mbcb on February 8, 2003, at 5:43:19
In reply to Re: Straterra » harper, posted by Cindylou on February 7, 2003, at 21:06:10
day 3 of straterra, I noticed slight ( very slight ability to focus , wasnt sure it was working , this was day 2 on 18 mg straterra on feb 6 , feb 7 i felt much beter in the a.m but by evening I felt wound up again..to a much higher degree than i thought i was prior to strattera, I read the drug doesnt cause rebound, would a higher dose make it last longer, seemed to last from about 6 am to about 2 am ...I dont want to be a roller coaster. what do you think. My adhd doc wants me to stay at 18 mg for a month..i thought titration was every 3 day to a week...
Deb
Posted by not exactly on February 8, 2003, at 11:25:42
In reply to Re: Straterra » Cindylou, posted by mom2mbcb on February 8, 2003, at 5:43:19
Deb,
Strattera half life is typically 5 hours. If the good effects wear off too quickly, going to b.i.d. or increasing the dose should help. Waiting a month before dose adjustment seems way too conservative.
- Bob
Posted by mom2mbcb on February 8, 2003, at 15:23:15
In reply to Re: Straterra » mom2mbcb, posted by not exactly on February 8, 2003, at 11:25:42
Thank you for your response. I was dissappointed as today day 4 I did not even have any positive effects and felt wound up all day as my usual adhd self does, also I noticed yesterday but more so today i get really sleepy on it, i took it a 6 am and absolutley had to sleep about 2:00 p.m. and wqas out to the world until 4:30 p.m. Is this a usual side effect. I really wanted this stuff to work as i couldnt tolerate side effects of stims. The adderral worked wonders for my focus but i felt realy driven. Iwould kill for that one thought and one thing at a time ability aderral gave me. Any advice would help as I am upsetting myself. I dont know if the pill is making me feel a little down in the dumps or my attitude.
Deb
Posted by not exactly on February 8, 2003, at 16:08:59
In reply to Re: Straterra, posted by mom2mbcb on February 8, 2003, at 15:23:15
How long has it been since you discontinued stim use? Some of your current negative symptoms could be due to stim withdrawal/rebound.
- Bob
Posted by mom2mbcb on February 9, 2003, at 4:11:58
In reply to Re: Straterra » mom2mbcb, posted by not exactly on February 8, 2003, at 16:08:59
well Its been quite a while at least 2 months. I hate to asound so negative, but I'm really trying to stick this one out.. But since I had posted about my feeling down in the dumps it had gradually increased by evening to an uncomfortable depression which I'm generally NOT ACCUSTOMEND TO EXCEPT ( EXCUSE ME MEN) around pms. And even then its not quite this bad. I dont want to quit thiS EARLY in the game if i can stand it . Does anyone know whether this pill is easy to get off If I find I need to. Also All my posts have been around 4 am I get to bed around 12 pm so I am waking up too early also. I normally only have anxiety like symptoms whivh really only show up with the adhd wind up or a too much to do at one time or to much over stimulation of outside necesseties.
Deb
Posted by Phil on February 9, 2003, at 18:51:33
In reply to Re: Straterra » not exactly, posted by mom2mbcb on February 9, 2003, at 4:11:58
No tapering required to stop Straterra.
Posted by paulk on February 9, 2003, at 19:35:22
In reply to Re: Straterra » not exactly, posted by mom2mbcb on February 9, 2003, at 4:11:58
What dosage are you taking? I'm starting out on a very low dosage (10mg) all I notice so far is possibly some iritability and I wake up a bit earlier.
Posted by mom2mbcb on February 10, 2003, at 3:48:38
In reply to Re: Straterra, posted by paulk on February 9, 2003, at 19:35:22
well I started on only 18 mg. Fianl update. I will not take it this morning. Yesterday i was a mental mess and Slept off and on in a fog most of the day. Felt a bit better by 8:00 p.m up today at 4:00 a.m. I have decided this is NOT going to work, So I will do my best to educate myself on behavior and cognitive therapy. Restructuring, Since i started with meds I have had side effects much worse ( although i find adhd makes my life very difficult with a 2 yr old and a 1 year old and very hard in other aspects as well) But I cant deal with the added significant side effects. I am disappoint4ted as i did get a chance to enjoy mental singlemindedness on adderrall, justhad to many physical side effects
Thanks everyone
Deb
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