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Dr. Bob is Robert Hsiung, MD,
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Posted by pharmrep on September 27, 2002, at 23:58:41
In reply to Re: Lexapro side-effects/dosage, posted by yeltom on September 27, 2002, at 22:18:05
*** you are right...Dr Dave wont agree with this point...Celexa is a racemic mixture with "mirror" halves..r-cit. and s-cit (50/50 mix) the r-cit does not contribute towards treating depressive symptoms at all (see sanchez study) and actually inhibits the s-cit (lexapro) from its full potential. it wasnt expected at first...but 10mg is at least as efficacious as 40mg of celexa.
But your conclusion is based on the idea that 10 mg. of Lexapro is equivalent to 20 mg. of Celexa, whereas the company claims that it's equivalent to 40 mg. Am I wrong? I am curious, however, why isolating one of the isomers would make it 4 times stronger. I assumed that the two isomers in celexa were present in a ratio of 1:1, in which case you'd assume (assuming that the less active isomer is not active at all) that the isomer would be twice as strong, not 4 times as strong. Unless the non-active component actually INHIBITS the active component. Or perhaps the assumption that they are present in a ratio of 1:1 is wrong.
>
Posted by curiousguy on September 28, 2002, at 0:14:35
In reply to Re: Lexapro side-effects/dosage » yeltom, posted by pharmrep on September 27, 2002, at 23:58:41
I just switched from celexa to lexapro... on celexa, i had some sexual side effects, mainly less desire and ejac.problems... i switched to lexapro recently - is rash (itchiness really) and/or shortness of breath possible side effects? Are there any ingredients in lexapro that could cause this? I never experienced either on celexa... also, does lexapro REALLY help the sexual side effects? How long to be on it before you notoice a difference?
Posted by pharmrep on September 28, 2002, at 0:56:31
In reply to Re: Lexapro side-effects/dosage, posted by curiousguy on September 28, 2002, at 0:14:35
> I just switched from celexa to lexapro... on celexa, i had some sexual side effects, mainly less desire and ejac.problems... i switched to lexapro recently - is rash (itchiness really) and/or shortness of breath possible side effects? Are there any ingredients in lexapro that could cause this? I never experienced either on celexa... also, does lexapro REALLY help the sexual side effects? How long to be on it before you notoice a difference?
>
> *** rash/itch...very low %, not mentionable, might go away with time/ same with shortness of breath. there are no "new ingrediants" in Lexapro. as for sex s/e...it is an ssri, and they are a class effect for all ssri's. It was listed as 9% for ejac delay...but might be higher. for all side effects and efficacy, you might see its true color in 1-2 weeks, but give it 3-4 for a fair trial for yourself. good luck and keep us posted
Posted by McPac on September 28, 2002, at 1:16:53
In reply to Re: Geezer » McPac, posted by Geezer on September 27, 2002, at 21:39:27
This IS the future! And the future is now!
Posted by IsoM on September 28, 2002, at 1:18:54
In reply to Re: Lexapro side-effects/dosage, posted by yeltom on September 27, 2002, at 22:18:05
Yeltom, see my above post in this thread:
http://www.dr-bob.org/babble/20020922/msgs/121268.html
further to your question.
The info comes from the Aug 2002 issue of Current Opinion in Investigational Drugs
Posted by Dinah on September 28, 2002, at 6:57:07
In reply to Re: Lexapro side-effects/dosage, posted by curiousguy on September 28, 2002, at 0:14:35
> i switched to lexapro recently - is rash (itchiness really) and/or shortness of breath possible side effects? Are there any ingredients in lexapro that could cause this? I never experienced either on celexa...
Hi curiousguy,
I would think that you should mention any new side effects like this to your pdoc and discuss with him whether or not you should continue. It may or it may not be related to the med, but you should still probably discuss it with a doctor.
Posted by Dinah on September 28, 2002, at 6:58:21
In reply to Re: Lexapro side-effects/dosage, posted by Dinah on September 28, 2002, at 6:57:07
Posted by Roman on September 28, 2002, at 10:41:53
In reply to Re: Lexapro side-effects/dosage » curiousguy, posted by pharmrep on September 28, 2002, at 0:56:31
> > It was listed as 9% for ejac delay...but might be higher.
For clarification, was that 9% of the males or 9% of all participants?
Posted by moxy1000 on September 28, 2002, at 13:55:25
In reply to Re: Lexapro side-effects/dosage » curiousguy, posted by pharmrep on September 28, 2002, at 0:56:31
the shortness of breath/itchiness that curious guy mentioned sounds a lot like I feel when my allergies are kicking in. Since neither is listed as being commonly reported s/e's, it's possible that these symptoms are totally unrelated. Also, when I feel stress/anxiety, I do feel short of breath also. Anyway, just my two cents.
Posted by sch00lteacher on September 28, 2002, at 14:03:26
In reply to Re: Lexapro side-effects/dosage, posted by moxy1000 on September 28, 2002, at 13:55:25
Dizziness, nausea, the nausea is the worst. If my stomach gets empty I feel close to losing it. I just started the Lexapro a week ago. So I am not used to it yet. I was on Effexor (spelling) for close to six months, maybe more. It just wasn't doing anything anymore.
Posted by Joe U on September 28, 2002, at 14:28:07
In reply to Re: Lexapro side-effects/dosage, posted by Dinah on September 28, 2002, at 6:57:07
I switched from Celexa to Lexapro about 2 weeks ago. I think it's making the Wellburtin ? and Neourtin ? kick in harder. Almost died from the withdrawal of Celexa-- 30Mg. This is the best clinical trial you can have, with real results. Sorry about the spelling, wasn't near the jars.
Posted by johnnylex on September 28, 2002, at 18:13:37
In reply to Anyone switched to Lexapro? « ggrrl, posted by Dr. Bob on June 11, 2002, at 7:52:48
I started on 10mg Lexapro about 2 weeks ago. Prior to this I was taking 150mg of Effexor, which was adequetly relieving my anxiety and depression, but had unwelcome side effects.
I am pleased that I feel no side effects with Lexapro, but I am not feeling much in the way of anxiety/depression relief with it. Is it time to ask my doctor about trying a higher dosage? How long should I give this?
Posted by Mircea on September 28, 2002, at 19:55:56
In reply to The hard, cold facts about Lexapro, posted by ZyprexaNumbTongue on September 6, 2002, at 14:37:39
>
> 4) The studies dont describe the TYPES of depressives in the Lexapro studies.This is not true, you can look at the baseline MADRS CGI and HAMD scores to determine how depressed the population is.
> We need more drug clinical trials where the people recruited are those with SEVERE melancholia type major depression, not dysthymics and moderate depressives.
Gorman did a subanalysis of severe depressives (see Gorman et al., 2002, CNS Spectrums) as part of the Lexapro pooled trial. Also, Gorman did an analysis of severe depressives that was presented at the recent CINP meeting in Montreal.
Posted by pharmrep on September 28, 2002, at 20:00:47
In reply to Re: Lexapro side-effects/dosage » pharmrep, posted by Roman on September 28, 2002, at 10:41:53
> > > It was listed as 9% for ejac delay...but might be higher.
>
> For clarification, was that 9% of the males or 9% of all participants?** good q...i would think just the men...but i will find out (i see how it would be diff)
ultimately it is a class s/e, so dont expect too much.
Posted by pharmrep on September 28, 2002, at 20:04:16
In reply to Re: Lexapro side-effects/dosage, posted by sch00lteacher on September 28, 2002, at 14:03:26
> Dizziness, nausea, the nausea is the worst. If my stomach gets empty I feel close to losing it. I just started the Lexapro a week ago. So I am not used to it yet. I was on Effexor (spelling) for close to six months, maybe more. It just wasn't doing anything anymore.
** you said 1 wk now for lexapro...did you just stop effexor? what dose?...dizziness and nausea can occur from abrupt discontinuation from effexor (and paxil). hopefully you can hang in there...do you see any benefits from lexapro yet?
Posted by pharmrep on September 28, 2002, at 20:06:19
In reply to Re: Lexapro side-effects/dosage, posted by Joe U on September 28, 2002, at 14:28:07
> I switched from Celexa to Lexapro about 2 weeks ago. I think it's making the Wellburtin ? and Neourtin ? kick in harder. Almost died from the withdrawal of Celexa-- 30Mg. This is the best clinical trial you can have, with real results. Sorry about the spelling, wasn't near the jars.
** hang in there...what dose for lexapro? 10mg?..are you noticing less somnolence?
Posted by pharmrep on September 28, 2002, at 20:11:00
In reply to pharmrep , a question about Lexapro dosage, posted by johnnylex on September 28, 2002, at 18:13:37
> I started on 10mg Lexapro about 2 weeks ago. Prior to this I was taking 150mg of Effexor, which was adequetly relieving my anxiety and depression, but had unwelcome side effects.
>
> I am pleased that I feel no side effects with Lexapro, but I am not feeling much in the way of anxiety/depression relief with it. Is it time to ask my doctor about trying a higher dosage? How long should I give this?** good q...glad you are experiencing better tolerability...here's the scoop. lexapro 10mg works in 1-2 weeks for most people, but as i have found, that's only a general statement to most here...for a fair trial, give it 3-4 weeks, if still not doing it, bump to 15mg for a couple weeks, then only higher if still not quite working.
Posted by yeltom on September 28, 2002, at 20:21:01
In reply to Re: Lexapro side-effects/dosage » Roman, posted by pharmrep on September 28, 2002, at 20:00:47
Generally, those types of figures are sex-specific. I.e., the demoninator would be men only.
> > > > It was listed as 9% for ejac delay...but might be higher.
> >
> > For clarification, was that 9% of the males or 9% of all participants?
>
> ** good q...i would think just the men...but i will find out (i see how it would be diff)
> ultimately it is a class s/e, so dont expect too much.
Posted by trmpqwn on September 29, 2002, at 7:05:30
In reply to Anyone switched to Lexapro? « ggrrl, posted by Dr. Bob on June 11, 2002, at 7:52:48
Yes, I've been on Lexapro (10 Mg) for 2+ weeks. My doctor switched me from Zoloft which I was taking for panic and depression. I have been sleeping better on the Lexapro and no more delayed orgasm! Yippee! I feel great. Lots of energy and really can't identify any side effects.
I have tried Serzone, Effexor as well as Zoloft and had delayed orgasm on all of these drugs.
Posted by trmpqwn on September 29, 2002, at 7:17:54
In reply to Re: Anyone switched to Lexapro? « ggrrl, posted by trmpqwn on September 29, 2002, at 7:05:30
Read my previous posting.
Posted by Geezer on September 29, 2002, at 16:26:52
In reply to GEEZER---Here's the link!, posted by McPac on September 28, 2002, at 1:16:53
McPac,
Thank you for the link!!
Geezer
Posted by cody on September 30, 2002, at 11:50:26
In reply to Re: Lexapro side-effects - where's the evidence? » dr. dave, posted by IsoM on September 27, 2002, at 13:02:22
This is my first post here. I have been on Remeron (45 mg) for 3 years. My doc wants me to try Lexapro. My main problem is extreme anxiety. I tried the Lexapro (5 mg.) a few weeks ago but quit after 3 days because of side effects. I want to give it another try at 2.5 mg. because of reading that the side effects may go away after 4-5 days. My question is, what is the best time of the day to take it. Would appreciate any input.
Thanks,
Cody
Posted by yeltom on September 30, 2002, at 12:18:23
In reply to What is the best time to take, posted by cody on September 30, 2002, at 11:50:26
I'm surprised you had any side effects at all from Lexapro at 5 mg. Are you sure it wasn't withdrawal from Remeron? In any case, they will almost certainly go away. For me, it doesnt matter what time I take it, but if the side effect is drowsiness, take it at night, and vice versa.
> This is my first post here. I have been on Remeron (45 mg) for 3 years. My doc wants me to try Lexapro. My main problem is extreme anxiety. I tried the Lexapro (5 mg.) a few weeks ago but quit after 3 days because of side effects. I want to give it another try at 2.5 mg. because of reading that the side effects may go away after 4-5 days. My question is, what is the best time of the day to take it. Would appreciate any input.
>
> Thanks,
> Cody
Posted by cody on September 30, 2002, at 13:31:03
In reply to Re: What is the best time to take, posted by yeltom on September 30, 2002, at 12:18:23
Not sure if it was Remeron withdrawal. I'm down to about 22.5 mg right now. I think that I'm very sensitive. Had to increase my Remeron very slowly. With the Lexapro, I was very nauseous, headache, spaced out feeling and my heart was racing. Can't afford to be down for long. Have husband and 4 children to take of. But I think I have to give it another try, because although the Remeron really helped with the anxiety, I have no energy or motivation for life. Doc told me to increase ativan while I'm adjusting to Lexapro. I really hope it works.
Posted by kimc on September 30, 2002, at 18:28:03
In reply to Re: Lexapro side-effects/dosage » Roman, posted by pharmrep on September 28, 2002, at 20:00:47
This is for Pharmrep or anyone: I have been on lexapro for 18 days at 10mg. Stopped taking Celexa around Nov 01 due to thinking it added to my protatisis probelm which I still have. I was on Zoloft 100mg for 7 or 8 years and switched because it wasn't working quite as good but was working. Anyways I started Remeron 15 mg and my protatisis (seems to be related to tension) got much better for a week and when I tried to raise it my vision was blurry so could'nt go to 30 mg which is what I needed. When lexapro came out I wanted to try it. It seems to stimulate me alot (or the prostate area) and I take it in the morning 5mg and 5mg in afternoon and 7.5 Remeron at night. My prostate seems to tightened up more on all the antidepressants except Remeron which is very sedating ( which I don't like) DO you think it will get better after a month or any suggestions from anyone. If I take Xanax with it that helps my prostate condition too but being a recovering alcoholic can't take that much and doctor wouldn't give me much either.
Thanks everyone for your time
Mr. Kim Cummings
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