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Dr. Bob is Robert Hsiung, MD,
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Posted by lois on May 14, 2001, at 20:05:41
In reply to Re: Topamax Experiences? » maribeth, posted by kathrynbabble on May 12, 2001, at 23:30:20
Hi,
I am on 75 mgs of topamax at night-supposed to help me sleep, but still need other meds to sleep.I too have some tingling in feet and hands,but am getting used to it.I don't know if it's from topamax or lamictal, which I also recently started.
Lois
Posted by Nellie on May 14, 2001, at 23:46:53
In reply to Re: Topamax Experiences? » maribeth, posted by kathrynbabble on May 12, 2001, at 23:30:20
> "I have been diagnosed as manic-depressive. I was doing well on 20mg of elexa. However, doing well turned into doing too well(hypomania) and then turned into even more extreme hypomania"
My understanding is that anti-depressants, (like Celexa) can cause manic/depressives to go into a manic state.
"he made me drop to 10mg of Celexa and I had withdrawl in the form of extreme agitation."
Did your doctor think the aggitation was from withdrawal? It would seem to me that aggitation would be more likely to be a part of the manic state.
"I did not know if it was going to get better or worse. Nothing even close has ever happened to me like this before."
I'm sure that was very frightening.
"I ended up trying Topamax starting with 25mg per night for 5 nights, then 50mg for 5 nights, then 25mg in am and 50mg in pm thereafter from then on with 10mg of celexa. On my 4th morning of that I went into a blind rage and crying spell."
Was it the fourth morning of your full Topamax dosage or just the fourth morning of taking the Topamax at all? It takes awhile for the Topamax to start working so, either way, it may not have been having an effect on your mania yet.
"I called the internist I have that listens to me better than the psychiatrist I have been sent to."
Look for a different psychiatrist. If you don't feel comfortable and he/she doesn't listen, then you need to make a switch.
"I am wondering (finally - I know) if anyone else out there has had a volitle reaction to getting used to Topamax? I am doing much better now that I am back on 20mg of Celexa with it. I am having the drowsiness and the strange tingles in the feet but nothing else besides the anger stated earlier. Any responses would be greatlle appreciated."
Here's my two cent's. I am not a doctor, but I've been treated by two psychiatrists and a GP for my depression/mood for about eight years, so I'll share what I have learned. I recently started taking Topamax because none of the anti-depressant I tried (zoloft, effexor, wellbutrin, serzone, prozac, etc, etc, etc,) helped with my irritability/anger/rage. My new psychiatrist suggested I try a mood stabalizer. I have not be diagnosed manic/depressive, but I have never been uniformly depressed. From what I've been told it can be trickier to treat bi-polar types because lifting the depressed mood can push us into the manic state. Since starting the Topamax, I have experienced some tingling in my fingers and some foods taste funny. My appetite has decreased a tiny bit and I was constipated for a few days. Other than that, I have not experienced anything but more calm and less worry/irritability/anger. That doesn't mean it will work for you, but I hope it will. I increased my dosage much slower: 25 mg at night for 10 days and now 25 mg morning/night for 7 days. Then I will start 50 mg at night until I see my pdoc in 3 1/2 weeks. My experience is that good psychiatrists who listen and stay current with the literature are much better to work with than GP/internists because they are specializing in our problems. However, any doctor that you feel doesn't listen to you is not worth one penny, so find someone who does. I'm lucky to have several friends in treatment, so I had lots of word-of-mouth recommendations! LOL! I'm really concerned about the Celexa if you had a manic episode--maybe someone who has been on it can speak to this. I would be more likely to blame the AD itself for the extreme aggitation rather than the dosage decrease or the Topamax. Don't you feel rich after my two cents?! Good luck figuring it all out. I know there are days that I feel like one big cocktail.
Posted by Tigwesley on May 15, 2001, at 15:09:54
In reply to Re: Recently Started on Topamax for Migraines, posted by Lainie on April 16, 2001, at 21:24:06
> > Lainie, I too have suffered from devastating migraines as my primary complaint since I was 19. And until 1996 I had never had a problem with depression. I am currently on Topamax after Pamelor and later Depakote both caused too many side effects (though all three had an effect on them). I also use a LOT of Imitrex injections and nasal sprays.
> >
> > After having my first child in 1996, I also developed a severe depression problem, and after my second child in 1998, it blossomed into bipolar II with rapid cycling. So I was treated with meds that could also tackle migraines. Thus I'm now on Zoloft, Wellbutrin and Topamax. For me the Topamax only began to help the migraines at 400 mg, and it never has helped the mood swings in my opinion. I've been on it at that dose for 3 months. I've lost 30 pounds in three months, had constant diarrhea, and had a constant "white noise" type of scream inside my head...I don't sleep well at all. I feel constantly agitated. Joyless about life, food, art, my family, everything. I finally dropped back to 300 mg on my own and am about to drop to 200 tonight. I have just taken things into my own hands; I felt my life was in danger I was so close to the edge. Ironically, the agitation caused me to take my migraine narcotics (which I needed less for the migraines at the 400mg dose) to dull that awful Topamax feeling. They were the only things in my chemical war chest that actually helped...
> >
> > Having said this, for others on this thread, they have found Topamax excellent, and if I didn't get the agitation, I could have appreciated the headache reduction. You clearly have a very different background and may find relief.
> >
> > I would also like to point out that I got good results from Depakote, though I had some problems there with weight gain, lethargy and hair loss at 500mg. And lastly, Pamelor, an old tricyclic, worked very well with side effects of constipation and dry mouth, but the bigger problem for me there was that if I missed a dose or dropped even 5 mg I would get massive withdrawal headaches immediately and my husband would need to miss work I would be so sick. Perhaps I'm just too sensitive to drugs...
> >
> > I wish you luck and if you want to talk more, I check this board weekly to get hope and inspiration from the others here, and to learn more. If you know of a good migraine support group on the web, let me know.
>
> Cateb, thanks so much for responding. It's great to hear from another migraineur, although your medical problems and drug combinations sound a lot more complicated than mine and I wish you a lot of luck. Terrible side effects at 400 mg. of Topamax and I'm having trouble at 75! (I go to 100 tomorrow morning.) I too tried Depakote, Zoloft and Wellbutrin, and also one or two of the tricyclic drugs. All of the Depakote-like drugs and high doses of Inderal/Propranolol made me so tired I couldn't even walk, much less run three times a week, so I quickly gave them up because to me life isn't worth living if I can't exercise (which I can't until I get over this rebound drug withdrawal thing).
>
> How much Imitrex are you taking? I had to give up the injections because I just hated the idea of giving them to myself and was so thankful when they came out with the tablets. My MD says no more than two to three times/wk., but I think after 5/1 he's probably going to say 2/wk. max - maybe it has to do with the rebound effect but that's something else I need to ask him.
>
> What are you going to replace the Topamax with? I've read about so many other similar drugs on this thread that I know they're out there - have you talked to your doctor yet?
>
> Anyway, I'll have time to write more later, but wanted to tell you that although I don't know of a good migraine support group yet, there is the ACHE net which has tons of separate threads (I wish they would merge more of them) about migraines that you might want to check out. If you're not familiar with ACHE it's the American Council for Headache Education at www.achenet.org/; select Discussion Forums, where they have Expert Talk, which I haven't found too useful but you can look it over, and Headache Talk, where us common folk leave our messages.
>
> Also if it's not too late where you live I wanted you to know that there's supposed to be a program called Headache: The Painful Truth on the Discovery Channel tonight, Tuesday, April 16th at 8 and 11 p.m. ET and then again on Monday, June 4th at 9 p.m. and 12 a.m. ET. It's not available on video. Hope you get a chance to check it out.
> Again, hang in there and keep me posted about any changes.
>
> I'm so excited the clinic head/internist is finally due back Wed. after being at a conference for 10 days and I have survived without him so that's a good sign - but I have a long list of questions about Topamax and its side effects and other things!
>
> Take care,
> Lainie
Hi there!My name is Tig. I have Chronic Daily Migraines. But I have much sympathy for those of you on this thread with Bi-polar disorder since my hubby has suffered with it for years. Although, he has not been cycling for the last 6 years, and seems to be in some sort of remission. (I didn't know there was such a thing!) We are enjoying it while it lasts.
Anyway, I am currently on Topamax I have worked up to 300mg per day and have had all the side effects you all talk about. I still have the tingly feet. I still think I need to increase my dose. I don't think we are quite there yet. But I have high hopes. I also take Propranolol 120mg as a preventative, then of course I have the usual assortment of abortives, Imitrex, Amerge, Midrin, Maxalt, Zomig, Hydroxyzpam etc. I have been on just about every drug out there for abortive and preventative, I just came off of Neurontin it lowered the Migraines but it made me very stupid, and driving was an adventure. I have to work right now and I was making way too many mistakes at work and had to come off it which was not fun. This has been a very rough month.
Lanie, it is funny that you mentioned the ice pack because I live with an ice pack wrapped around my forehead when I am at home. I use a favorite silk scarf to hold in place and iron, do laundry etc. if I feel up to it. I look like a dork but hey what ever works right? When you are in pain every single day you have to do things to get the job done.
Regarding Migraine support groups/websites etc. there are two that I go to all the time. They are great. Very supportive and informational. MAGNUM Migraine Awareness Group www.migraines.org and www.headaches.about.com the last one is an actual forum/chat/database/clearinghouse of information on everything migraine you might ever want to know.
I hope this helps. I hope everyone on this thread finds relief from the pain they are feeling.
Posted by Cateb on May 20, 2001, at 1:38:09
In reply to Re: Recently Started on Topamax for Migraines, posted by Tigwesley on May 15, 2001, at 15:09:54
Tig, Lainie and others:
As an update to my Topamax / migraine / bipolar cycling situation, I had an *incredible* breakthrough three weeks ago. I continued to wean myself off the Topamax, convinced it was making me ruminate and feel suicidal (for the first time in my life). My weight loss had continued -- I'd lost another 10 pounds the next month for a grand total of 40 pounds; scary. More liquid diarrhea.
But then it struck me that Wellbutrin has always been activating as well with me and that it was when I went on Wellbutrin that I had to then start taking Xanax. So I spoke with my doctor and began to rapidly (more rapidly than he wanted) taper off the Wellbutrin. The results have been a miracle.
Cycling's gone. Suicidal thoughts are gone. Anxiety's gone. I have perspective. I roll with the punches. My sense of humor is back. Yet empirically, things in my life have gotten worse and I should be acting out more. I had to lay off several people. I had to undergo several medical tests because my doctor found nodules in my neck and thought the rapid weight loss might have been cancer. (It wasn't -- the diarrhea and weight loss stopped with the drugs I stopped). I am living in Boston (answer to your question) but have to leave my family, two young girls, to work out of NYC every single week because of the economy in a new job I started five weeks ago. Ironically, headaches exactly the same with and without the damned drugs - Ha! What a ghost I've been chasing.
I had never officially been diagnosed with Bipolar Two until I had been put on mood stabilizers for migraines. Now all the symptoms have completely disappeared. Has anyone else out there experienced bad psychological reactions to these drugs in combination particularly? My biggest hurdle was convincing my doctor, whose own self-worth is entirely too tied up in whether his own drugs are successful or not. We just had an hour's session where I told him this and many other things, and that he needed to pay *me* for that session. I told him it was the only way we could continue. And he agreed that he had not done his job. Thanks to this board's education and support, I learned some nifty concepts, such as "concordance, not compliance".
Now I'm just on Zoloft and it's like an old friend's back: my life. Comparatively, I'll take the ice pack, imitrex injections and codeine any day. I'm now beginning to read about alternative approaches again such as meditation. They're less likely to betray me.
Cate.
> > > Lainie, I too have suffered from devastating migraines as my primary complaint since I was 19. And until 1996 I had never had a problem with depression. I am currently on Topamax after Pamelor and later Depakote both caused too many side effects (though all three had an effect on them). I also use a LOT of Imitrex injections and nasal sprays.
> > >
> > > After having my first child in 1996, I also developed a severe depression problem, and after my second child in 1998, it blossomed into bipolar II with rapid cycling. So I was treated with meds that could also tackle migraines. Thus I'm now on Zoloft, Wellbutrin and Topamax. For me the Topamax only began to help the migraines at 400 mg, and it never has helped the mood swings in my opinion. I've been on it at that dose for 3 months. I've lost 30 pounds in three months, had constant diarrhea, and had a constant "white noise" type of scream inside my head...I don't sleep well at all. I feel constantly agitated. Joyless about life, food, art, my family, everything. I finally dropped back to 300 mg on my own and am about to drop to 200 tonight. I have just taken things into my own hands; I felt my life was in danger I was so close to the edge. Ironically, the agitation caused me to take my migraine narcotics (which I needed less for the migraines at the 400mg dose) to dull that awful Topamax feeling. They were the only things in my chemical war chest that actually helped...
> > >
> > > Having said this, for others on this thread, they have found Topamax excellent, and if I didn't get the agitation, I could have appreciated the headache reduction. You clearly have a very different background and may find relief.
> > >
> > > I would also like to point out that I got good results from Depakote, though I had some problems there with weight gain, lethargy and hair loss at 500mg. And lastly, Pamelor, an old tricyclic, worked very well with side effects of constipation and dry mouth, but the bigger problem for me there was that if I missed a dose or dropped even 5 mg I would get massive withdrawal headaches immediately and my husband would need to miss work I would be so sick. Perhaps I'm just too sensitive to drugs...
> > >
> > > I wish you luck and if you want to talk more, I check this board weekly to get hope and inspiration from the others here, and to learn more. If you know of a good migraine support group on the web, let me know.
> >
> > Cateb, thanks so much for responding. It's great to hear from another migraineur, although your medical problems and drug combinations sound a lot more complicated than mine and I wish you a lot of luck. Terrible side effects at 400 mg. of Topamax and I'm having trouble at 75! (I go to 100 tomorrow morning.) I too tried Depakote, Zoloft and Wellbutrin, and also one or two of the tricyclic drugs. All of the Depakote-like drugs and high doses of Inderal/Propranolol made me so tired I couldn't even walk, much less run three times a week, so I quickly gave them up because to me life isn't worth living if I can't exercise (which I can't until I get over this rebound drug withdrawal thing).
> >
> > How much Imitrex are you taking? I had to give up the injections because I just hated the idea of giving them to myself and was so thankful when they came out with the tablets. My MD says no more than two to three times/wk., but I think after 5/1 he's probably going to say 2/wk. max - maybe it has to do with the rebound effect but that's something else I need to ask him.
> >
> > What are you going to replace the Topamax with? I've read about so many other similar drugs on this thread that I know they're out there - have you talked to your doctor yet?
> >
> > Anyway, I'll have time to write more later, but wanted to tell you that although I don't know of a good migraine support group yet, there is the ACHE net which has tons of separate threads (I wish they would merge more of them) about migraines that you might want to check out. If you're not familiar with ACHE it's the American Council for Headache Education at www.achenet.org/; select Discussion Forums, where they have Expert Talk, which I haven't found too useful but you can look it over, and Headache Talk, where us common folk leave our messages.
> >
> > Also if it's not too late where you live I wanted you to know that there's supposed to be a program called Headache: The Painful Truth on the Discovery Channel tonight, Tuesday, April 16th at 8 and 11 p.m. ET and then again on Monday, June 4th at 9 p.m. and 12 a.m. ET. It's not available on video. Hope you get a chance to check it out.
> > Again, hang in there and keep me posted about any changes.
> >
> > I'm so excited the clinic head/internist is finally due back Wed. after being at a conference for 10 days and I have survived without him so that's a good sign - but I have a long list of questions about Topamax and its side effects and other things!
> >
> > Take care,
> > Lainie
>
>
> Hi there!
>
> My name is Tig. I have Chronic Daily Migraines. But I have much sympathy for those of you on this thread with Bi-polar disorder since my hubby has suffered with it for years. Although, he has not been cycling for the last 6 years, and seems to be in some sort of remission. (I didn't know there was such a thing!) We are enjoying it while it lasts.
>
> Anyway, I am currently on Topamax I have worked up to 300mg per day and have had all the side effects you all talk about. I still have the tingly feet. I still think I need to increase my dose. I don't think we are quite there yet. But I have high hopes. I also take Propranolol 120mg as a preventative, then of course I have the usual assortment of abortives, Imitrex, Amerge, Midrin, Maxalt, Zomig, Hydroxyzpam etc. I have been on just about every drug out there for abortive and preventative, I just came off of Neurontin it lowered the Migraines but it made me very stupid, and driving was an adventure. I have to work right now and I was making way too many mistakes at work and had to come off it which was not fun. This has been a very rough month.
>
> Lanie, it is funny that you mentioned the ice pack because I live with an ice pack wrapped around my forehead when I am at home. I use a favorite silk scarf to hold in place and iron, do laundry etc. if I feel up to it. I look like a dork but hey what ever works right? When you are in pain every single day you have to do things to get the job done.
>
> Regarding Migraine support groups/websites etc. there are two that I go to all the time. They are great. Very supportive and informational. MAGNUM Migraine Awareness Group www.migraines.org and www.headaches.about.com the last one is an actual forum/chat/database/clearinghouse of information on everything migraine you might ever want to know.
>
> I hope this helps. I hope everyone on this thread finds relief from the pain they are feeling.
Posted by bob on May 24, 2001, at 10:34:58
In reply to Tomamax for Migraines: Terrible Cross Rxn w/Wbtn?? » Tigwesley, posted by Cateb on May 20, 2001, at 1:38:09
> Tig, Lainie and others:
>
> As an update to my Topamax / migraine / bipolar cycling situation, I had an *incredible* breakthrough three weeks ago. I continued to wean myself off the Topamax, convinced it was making me ruminate and feel suicidal (for the first time in my life). My weight loss had continued -- I'd lost another 10 pounds the next month for a grand total of 40 pounds; scary. More liquid diarrhea.
>
> But then it struck me that Wellbutrin has always been activating as well with me and that it was when I went on Wellbutrin that I had to then start taking Xanax. So I spoke with my doctor and began to rapidly (more rapidly than he wanted) taper off the Wellbutrin. The results have been a miracle.
>
> Cycling's gone. Suicidal thoughts are gone. Anxiety's gone. I have perspective. I roll with the punches. My sense of humor is back. Yet empirically, things in my life have gotten worse and I should be acting out more. I had to lay off several people. I had to undergo several medical tests because my doctor found nodules in my neck and thought the rapid weight loss might have been cancer. (It wasn't -- the diarrhea and weight loss stopped with the drugs I stopped). I am living in Boston (answer to your question) but have to leave my family, two young girls, to work out of NYC every single week because of the economy in a new job I started five weeks ago. Ironically, headaches exactly the same with and without the damned drugs - Ha! What a ghost I've been chasing.
>
> I had never officially been diagnosed with Bipolar Two until I had been put on mood stabilizers for migraines. Now all the symptoms have completely disappeared. Has anyone else out there experienced bad psychological reactions to these drugs in combination particularly? My biggest hurdle was convincing my doctor, whose own self-worth is entirely too tied up in whether his own drugs are successful or not. We just had an hour's session where I told him this and many other things, and that he needed to pay *me* for that session. I told him it was the only way we could continue. And he agreed that he had not done his job. Thanks to this board's education and support, I learned some nifty concepts, such as "concordance, not compliance".
>
> Now I'm just on Zoloft and it's like an old friend's back: my life. Comparatively, I'll take the ice pack, imitrex injections and codeine any day. I'm now beginning to read about alternative approaches again such as meditation. They're less likely to betray me.
>
> Cate.
>
> > > > Lainie, I too have suffered from devastating migraines as my primary complaint since I was 19. And until 1996 I had never had a problem with depression. I am currently on Topamax after Pamelor and later Depakote both caused too many side effects (though all three had an effect on them). I also use a LOT of Imitrex injections and nasal sprays.
> > > >
> > > > After having my first child in 1996, I also developed a severe depression problem, and after my second child in 1998, it blossomed into bipolar II with rapid cycling. So I was treated with meds that could also tackle migraines. Thus I'm now on Zoloft, Wellbutrin and Topamax. For me the Topamax only began to help the migraines at 400 mg, and it never has helped the mood swings in my opinion. I've been on it at that dose for 3 months. I've lost 30 pounds in three months, had constant diarrhea, and had a constant "white noise" type of scream inside my head...I don't sleep well at all. I feel constantly agitated. Joyless about life, food, art, my family, everything. I finally dropped back to 300 mg on my own and am about to drop to 200 tonight. I have just taken things into my own hands; I felt my life was in danger I was so close to the edge. Ironically, the agitation caused me to take my migraine narcotics (which I needed less for the migraines at the 400mg dose) to dull that awful Topamax feeling. They were the only things in my chemical war chest that actually helped...
> > > >
> > > > Having said this, for others on this thread, they have found Topamax excellent, and if I didn't get the agitation, I could have appreciated the headache reduction. You clearly have a very different background and may find relief.
> > > >
> > > > I would also like to point out that I got good results from Depakote, though I had some problems there with weight gain, lethargy and hair loss at 500mg. And lastly, Pamelor, an old tricyclic, worked very well with side effects of constipation and dry mouth, but the bigger problem for me there was that if I missed a dose or dropped even 5 mg I would get massive withdrawal headaches immediately and my husband would need to miss work I would be so sick. Perhaps I'm just too sensitive to drugs...
> > > >
> > > > I wish you luck and if you want to talk more, I check this board weekly to get hope and inspiration from the others here, and to learn more. If you know of a good migraine support group on the web, let me know.
> > >
> > > Cateb, thanks so much for responding. It's great to hear from another migraineur, although your medical problems and drug combinations sound a lot more complicated than mine and I wish you a lot of luck. Terrible side effects at 400 mg. of Topamax and I'm having trouble at 75! (I go to 100 tomorrow morning.) I too tried Depakote, Zoloft and Wellbutrin, and also one or two of the tricyclic drugs. All of the Depakote-like drugs and high doses of Inderal/Propranolol made me so tired I couldn't even walk, much less run three times a week, so I quickly gave them up because to me life isn't worth living if I can't exercise (which I can't until I get over this rebound drug withdrawal thing).
> > >
> > > How much Imitrex are you taking? I had to give up the injections because I just hated the idea of giving them to myself and was so thankful when they came out with the tablets. My MD says no more than two to three times/wk., but I think after 5/1 he's probably going to say 2/wk. max - maybe it has to do with the rebound effect but that's something else I need to ask him.
> > >
> > > What are you going to replace the Topamax with? I've read about so many other similar drugs on this thread that I know they're out there - have you talked to your doctor yet?
> > >
> > > Anyway, I'll have time to write more later, but wanted to tell you that although I don't know of a good migraine support group yet, there is the ACHE net which has tons of separate threads (I wish they would merge more of them) about migraines that you might want to check out. If you're not familiar with ACHE it's the American Council for Headache Education at www.achenet.org/; select Discussion Forums, where they have Expert Talk, which I haven't found too useful but you can look it over, and Headache Talk, where us common folk leave our messages.
> > >
> > > Also if it's not too late where you live I wanted you to know that there's supposed to be a program called Headache: The Painful Truth on the Discovery Channel tonight, Tuesday, April 16th at 8 and 11 p.m. ET and then again on Monday, June 4th at 9 p.m. and 12 a.m. ET. It's not available on video. Hope you get a chance to check it out.
> > > Again, hang in there and keep me posted about any changes.
> > >
> > > I'm so excited the clinic head/internist is finally due back Wed. after being at a conference for 10 days and I have survived without him so that's a good sign - but I have a long list of questions about Topamax and its side effects and other things!
> > >
> > > Take care,
> > > Lainie
> >
> >
> > Hi there!
> >
> > My name is Tig. I have Chronic Daily Migraines. But I have much sympathy for those of you on this thread with Bi-polar disorder since my hubby has suffered with it for years. Although, he has not been cycling for the last 6 years, and seems to be in some sort of remission. (I didn't know there was such a thing!) We are enjoying it while it lasts.
> >
> > Anyway, I am currently on Topamax I have worked up to 300mg per day and have had all the side effects you all talk about. I still have the tingly feet. I still think I need to increase my dose. I don't think we are quite there yet. But I have high hopes. I also take Propranolol 120mg as a preventative, then of course I have the usual assortment of abortives, Imitrex, Amerge, Midrin, Maxalt, Zomig, Hydroxyzpam etc. I have been on just about every drug out there for abortive and preventative, I just came off of Neurontin it lowered the Migraines but it made me very stupid, and driving was an adventure. I have to work right now and I was making way too many mistakes at work and had to come off it which was not fun. This has been a very rough month.
> >
> > Lanie, it is funny that you mentioned the ice pack because I live with an ice pack wrapped around my forehead when I am at home. I use a favorite silk scarf to hold in place and iron, do laundry etc. if I feel up to it. I look like a dork but hey what ever works right? When you are in pain every single day you have to do things to get the job done.
> >
> > Regarding Migraine support groups/websites etc. there are two that I go to all the time. They are great. Very supportive and informational. MAGNUM Migraine Awareness Group www.migraines.org and www.headaches.about.com the last one is an actual forum/chat/database/clearinghouse of information on everything migraine you might ever want to know.
> >
> > I hope this helps. I hope everyone on this thread finds relief from the pain they are feeling.
Cateb:I too, have been on Topomax (250mg) for quite awhile, and am now weaning my self off also. I was just curious as to what level you had stabilized at, and how quickly you were coming off?
Bob
Posted by limey on May 25, 2001, at 9:54:02
In reply to Re: Tomamax for Migraines: Terrible Cross Rxn w/Wbtn??, posted by bob on May 24, 2001, at 10:34:58
I have suffered from severe depression and anxiety for 20 years, and have been on many different anti-depressants. Paxil worked very well and I have been on it for 5 years - but, my weight has totally ballooned!! (Don't know my weight since I avoid the scales like the plague!) But, I have put up with this side-effect because it felt sooooo good not to be under that constant black cloud! However, I finally suggest to my pdoc that surely he can give me an AD that will help me but won't make me gain so much weight!! He has now switched me to effexor 225gm at night, and that it working great! Now he wants to add Topamax to help with the weight gain. I found this link by surfing the net to get more info' on Topamax, and have read everything you have all written since the thread started in Jan. The side effects seem pretty severe just to loose weight. Has anyone any suggestions for me? I see my doc next week and he wants to start the Topamax then. Please help!
- Limey
Posted by Lexie on May 26, 2001, at 7:31:31
In reply to Re: Tomamax for weight loss, posted by limey on May 25, 2001, at 9:54:02
Everyone else has heard me say this so plug up your ears. So for Limey, I was put on Topamax almost a year ago, I am now, everyone, as of last month up to 500 mgs, and I have lost 35 pounds and am NOW 120 pounds at 5'9", underweight for my height. Yes, it does cause weight loss, just be careful what you ask for you just might get it. I have become a bit obessed with the entire weight loss thing. I am catching a bit of grief from my family. My doctor hasn't noticed because of the clothes I wear to my visits. I had been 137 before going on the AD's (while on the AD's I got up to 155) when I was put on Topamax I should have maintained when I reached 137. Most importantly it has been a great drug for Bipolar 2, the ups and downs and acting out. The only one that has worked for me. Just be sure to maintain a healthy weight, my best advise. Take care of yourself. Lexie
Posted by limey on May 26, 2001, at 8:56:03
In reply to Re: Tomamax for weight loss, posted by Lexie on May 26, 2001, at 7:31:31
To Lexie, Thanks for the advice and answering my call! I am new to this site (I expect you've guessed!) and after posting my note, I searched the archives and found all kinds of opinions on this med. I am so tired of being XX-LARGE - at times, I say "To heck with it, I'm going off!" but, then the depression/anxiety/panic comes back and being over-weight suddenly pales in comparison. It was so marvellous to find this site and read all the experiences of other sufferers - these meds. really are a two-edged sword - but, considering what the first ones were like when I was initially "diagnosed" 20 years ago, these newer ones are a blessing. (If only they could find an effective one without the huge weight gains!!!!) But, I am hopeful that the Topamax together with effexor will help - it doesn't hurt to look on the bright side - right? - Limey
Posted by Lexie on May 26, 2001, at 16:33:45
In reply to Re: Tomamax for weight loss, posted by limey on May 26, 2001, at 8:56:03
Limey, I think you are the right track trying out the Topamax. What worked for me was Topamax with Lamictal, another anti-sezuire medication that has AD qualities but no history of weight gain. You may want to ask your doctor about it. Everyone is different, I am offering some friendly advise from someone who has been there. I think you have the right attitude to go into this looking on the bright side, I did and maybe that is why I was so successful. Topamax is not a magic bullet. For me it helped with the sweet cravings that were so overwhelming with the AD's and the cravings to "Snack" at times when I normally wouldn't. Let us know how you are doing.
Posted by Cateb on May 27, 2001, at 7:13:26
In reply to Re: Tomamax for Migraines: Terrible Cross Rxn w/Wbtn??, posted by bob on May 24, 2001, at 10:34:58
Bob,
Apologies for the slow response; I can only check the board on weekends.
I was on 200mg of Topamax for a long time and then my doctor quickly moved me up to 400mg. He did this because I was having crying jags and was really not holding together at all even in conversations with friends, kept wishing I "could go home" (when I was home -- we'd sold our house and things hadn't worked out as well as planned but I couldn't let go of it). I was also on 100 mg of Zoloft at the time and, more importantly, 300 mg of Wellbutrin. That's what I think was somehow contributing to things along with the Topamax. In my case anyway.
I stayed on the 400mg for two months and then tapered off after the weight loss and other symptoms became so extreme, including suidical thoughts. These were things I couldn't talk about at the time because to give words to them would make them more of a real option. But they were incredibly frightening and caused me to look beyond the Topamax; my gut just told me that the way I had reacted to the circumstances of my life was just *so* different that there was something chemically that I was doing to meddle with myself. And I knew that the Zoloft alone had been fine. So that's when I insisted that the Wellbutrin had to go, too . When it did,all the symptoms disappeared. I should add that things like cycling mental state also evaporated dispite a scare that I might have cancer (my internist found nodules in my neck when he was checking for reasons for this chronic diarrhea and sudden severe 40 pound weight loss) and when the following week I had to lay off a third of my organization at work. In other words, even my doctor couldn't say honestly that it was just that my circumstances improved because they deteriorated dramatically! And I felt *great*, lots of good perspective and actual joy, believe it or not. That was toward the end of April and I've felt pretty calm, able to surf life's waves every day since, just on the Zoloft. Phew.
I know that's more than you asked, but I want to make sure I clarify that I don't know in my case what was Wellbutrin and what was Topamax. Indeed, I don't know if Wellbutrin made me *look* bipolar because I was so sensitive to its activating tendencies and then they gave me Topamax, justifying it also on the basis of the migraines. I know they interacted; I could feel Wellbutrin getting nastier(and I was never on Topamax alone). But to be fair to Topamax, I only know that now they're both gone and I'm a happy person for the first time *since I've been on Wellbutrin*.
> > Tig, Lainie and others:
> >
> > As an update to my Topamax / migraine / bipolar cycling situation, I had an *incredible* breakthrough three weeks ago. I continued to wean myself off the Topamax, convinced it was making me ruminate and feel suicidal (for the first time in my life). My weight loss had continued -- I'd lost another 10 pounds the next month for a grand total of 40 pounds; scary. More liquid diarrhea.
> >
> > But then it struck me that Wellbutrin has always been activating as well with me and that it was when I went on Wellbutrin that I had to then start taking Xanax. So I spoke with my doctor and began to rapidly (more rapidly than he wanted) taper off the Wellbutrin. The results have been a miracle.
> >
> > Cycling's gone. Suicidal thoughts are gone. Anxiety's gone. I have perspective. I roll with the punches. My sense of humor is back. Yet empirically, things in my life have gotten worse and I should be acting out more. I had to lay off several people. I had to undergo several medical tests because my doctor found nodules in my neck and thought the rapid weight loss might have been cancer. (It wasn't -- the diarrhea and weight loss stopped with the drugs I stopped). I am living in Boston (answer to your question) but have to leave my family, two young girls, to work out of NYC every single week because of the economy in a new job I started five weeks ago. Ironically, headaches exactly the same with and without the damned drugs - Ha! What a ghost I've been chasing.
> >
> > I had never officially been diagnosed with Bipolar Two until I had been put on mood stabilizers for migraines. Now all the symptoms have completely disappeared. Has anyone else out there experienced bad psychological reactions to these drugs in combination particularly? My biggest hurdle was convincing my doctor, whose own self-worth is entirely too tied up in whether his own drugs are successful or not. We just had an hour's session where I told him this and many other things, and that he needed to pay *me* for that session. I told him it was the only way we could continue. And he agreed that he had not done his job. Thanks to this board's education and support, I learned some nifty concepts, such as "concordance, not compliance".
> >
> > Now I'm just on Zoloft and it's like an old friend's back: my life. Comparatively, I'll take the ice pack, imitrex injections and codeine any day. I'm now beginning to read about alternative approaches again such as meditation. They're less likely to betray me.
> >
> > Cate.
> >
> > > > > Lainie, I too have suffered from devastating migraines as my primary complaint since I was 19. And until 1996 I had never had a problem with depression. I am currently on Topamax after Pamelor and later Depakote both caused too many side effects (though all three had an effect on them). I also use a LOT of Imitrex injections and nasal sprays.
> > > > >
> > > > > After having my first child in 1996, I also developed a severe depression problem, and after my second child in 1998, it blossomed into bipolar II with rapid cycling. So I was treated with meds that could also tackle migraines. Thus I'm now on Zoloft, Wellbutrin and Topamax. For me the Topamax only began to help the migraines at 400 mg, and it never has helped the mood swings in my opinion. I've been on it at that dose for 3 months. I've lost 30 pounds in three months, had constant diarrhea, and had a constant "white noise" type of scream inside my head...I don't sleep well at all. I feel constantly agitated. Joyless about life, food, art, my family, everything. I finally dropped back to 300 mg on my own and am about to drop to 200 tonight. I have just taken things into my own hands; I felt my life was in danger I was so close to the edge. Ironically, the agitation caused me to take my migraine narcotics (which I needed less for the migraines at the 400mg dose) to dull that awful Topamax feeling. They were the only things in my chemical war chest that actually helped...
> > > > >
> > > > > Having said this, for others on this thread, they have found Topamax excellent, and if I didn't get the agitation, I could have appreciated the headache reduction. You clearly have a very different background and may find relief.
> > > > >
> > > > > I would also like to point out that I got good results from Depakote, though I had some problems there with weight gain, lethargy and hair loss at 500mg. And lastly, Pamelor, an old tricyclic, worked very well with side effects of constipation and dry mouth, but the bigger problem for me there was that if I missed a dose or dropped even 5 mg I would get massive withdrawal headaches immediately and my husband would need to miss work I would be so sick. Perhaps I'm just too sensitive to drugs...
> > > > >
> > > > > I wish you luck and if you want to talk more, I check this board weekly to get hope and inspiration from the others here, and to learn more. If you know of a good migraine support group on the web, let me know.
> > > >
> > > > Cateb, thanks so much for responding. It's great to hear from another migraineur, although your medical problems and drug combinations sound a lot more complicated than mine and I wish you a lot of luck. Terrible side effects at 400 mg. of Topamax and I'm having trouble at 75! (I go to 100 tomorrow morning.) I too tried Depakote, Zoloft and Wellbutrin, and also one or two of the tricyclic drugs. All of the Depakote-like drugs and high doses of Inderal/Propranolol made me so tired I couldn't even walk, much less run three times a week, so I quickly gave them up because to me life isn't worth living if I can't exercise (which I can't until I get over this rebound drug withdrawal thing).
> > > >
> > > > How much Imitrex are you taking? I had to give up the injections because I just hated the idea of giving them to myself and was so thankful when they came out with the tablets. My MD says no more than two to three times/wk., but I think after 5/1 he's probably going to say 2/wk. max - maybe it has to do with the rebound effect but that's something else I need to ask him.
> > > >
> > > > What are you going to replace the Topamax with? I've read about so many other similar drugs on this thread that I know they're out there - have you talked to your doctor yet?
> > > >
> > > > Anyway, I'll have time to write more later, but wanted to tell you that although I don't know of a good migraine support group yet, there is the ACHE net which has tons of separate threads (I wish they would merge more of them) about migraines that you might want to check out. If you're not familiar with ACHE it's the American Council for Headache Education at www.achenet.org/; select Discussion Forums, where they have Expert Talk, which I haven't found too useful but you can look it over, and Headache Talk, where us common folk leave our messages.
> > > >
> > > > Also if it's not too late where you live I wanted you to know that there's supposed to be a program called Headache: The Painful Truth on the Discovery Channel tonight, Tuesday, April 16th at 8 and 11 p.m. ET and then again on Monday, June 4th at 9 p.m. and 12 a.m. ET. It's not available on video. Hope you get a chance to check it out.
> > > > Again, hang in there and keep me posted about any changes.
> > > >
> > > > I'm so excited the clinic head/internist is finally due back Wed. after being at a conference for 10 days and I have survived without him so that's a good sign - but I have a long list of questions about Topamax and its side effects and other things!
> > > >
> > > > Take care,
> > > > Lainie
> > >
> > >
> > > Hi there!
> > >
> > > My name is Tig. I have Chronic Daily Migraines. But I have much sympathy for those of you on this thread with Bi-polar disorder since my hubby has suffered with it for years. Although, he has not been cycling for the last 6 years, and seems to be in some sort of remission. (I didn't know there was such a thing!) We are enjoying it while it lasts.
> > >
> > > Anyway, I am currently on Topamax I have worked up to 300mg per day and have had all the side effects you all talk about. I still have the tingly feet. I still think I need to increase my dose. I don't think we are quite there yet. But I have high hopes. I also take Propranolol 120mg as a preventative, then of course I have the usual assortment of abortives, Imitrex, Amerge, Midrin, Maxalt, Zomig, Hydroxyzpam etc. I have been on just about every drug out there for abortive and preventative, I just came off of Neurontin it lowered the Migraines but it made me very stupid, and driving was an adventure. I have to work right now and I was making way too many mistakes at work and had to come off it which was not fun. This has been a very rough month.
> > >
> > > Lanie, it is funny that you mentioned the ice pack because I live with an ice pack wrapped around my forehead when I am at home. I use a favorite silk scarf to hold in place and iron, do laundry etc. if I feel up to it. I look like a dork but hey what ever works right? When you are in pain every single day you have to do things to get the job done.
> > >
> > > Regarding Migraine support groups/websites etc. there are two that I go to all the time. They are great. Very supportive and informational. MAGNUM Migraine Awareness Group www.migraines.org and www.headaches.about.com the last one is an actual forum/chat/database/clearinghouse of information on everything migraine you might ever want to know.
> > >
> > > I hope this helps. I hope everyone on this thread finds relief from the pain they are feeling.
>
>
>
>
> Cateb:
>
> I too, have been on Topomax (250mg) for quite awhile, and am now weaning my self off also. I was just curious as to what level you had stabilized at, and how quickly you were coming off?
>
> Bob
Posted by Cateb on May 27, 2001, at 7:34:29
In reply to Re: Tomamax for weight loss, posted by Lexie on May 26, 2001, at 7:31:31
When Lexie said her doctor didn't even notice her extremely dramatic weight lost, that really struck a chord with me. I lost 40 pounds on Topamax and I'm 5'8". But my doctor didn't notice, either. I think, regardless of the clothes I'm wearing, that this is irresponsible, and it's been bugging me for a while. Until I read this, it didn't face my own feelings about my doctor. He also wouldn't listen to me when I said that I thought the Wellbutrin/Topamax combo he had me on was really messing with my head. Pretty serious when I began to have suicidal thoughts and then didn't even feel I could talk with him about them because he spends so much time talking and not enough time listening or knowing the right thing to *do*.
I guess I'm mad that he would just throw drugs at me and not monitor me closely enough to understand (hey, or even ask me!) what the side effect were. In my case, he didn't even offer what side effects I might experience, and my history says I'm prone to them if there's such a thing. It's only as I began to get burned by some drugs and started grilling him and found this board (and learned the phrase "concordance versus compliance" from Cam W.) that he got on his toes.
I think I know the kinds of posts this will elicit...my husband has been urging me to switch doctors for a while now.
> Everyone else has heard me say this so plug up your ears. So for Limey, I was put on Topamax almost a year ago, I am now, everyone, as of last month up to 500 mgs, and I have lost 35 pounds and am NOW 120 pounds at 5'9", underweight for my height. Yes, it does cause weight loss, just be careful what you ask for you just might get it. I have become a bit obessed with the entire weight loss thing. I am catching a bit of grief from my family. My doctor hasn't noticed because of the clothes I wear to my visits. I had been 137 before going on the AD's (while on the AD's I got up to 155) when I was put on Topamax I should have maintained when I reached 137. Most importantly it has been a great drug for Bipolar 2, the ups and downs and acting out. The only one that has worked for me. Just be sure to maintain a healthy weight, my best advise. Take care of yourself. Lexie
Posted by limey on May 27, 2001, at 8:32:31
In reply to Re: Tomamax for weight loss, posted by Lexie on May 26, 2001, at 16:33:45
Thanks for the words of encouragement Lexie! I only found this site a few days ago and it feels like such a weight has been lifted to read about other people's experiences, and to realize that I am NOT alone in all this! 10 years ago I had breast cancer, and now volunteer with a support group for breast cancer survivors - finding this site is like finding a support group for myself. Thanks again - I hope others find these threads as comforting. - limey
> Limey, I think you are the right track trying out the Topamax. What worked for me was Topamax with Lamictal, another anti-sezuire medication that has AD qualities but no history of weight gain. You may want to ask your doctor about it. Everyone is different, I am offering some friendly advise from someone who has been there. I think you have the right attitude to go into this looking on the bright side, I did and maybe that is why I was so successful. Topamax is not a magic bullet. For me it helped with the sweet cravings that were so overwhelming with the AD's and the cravings to "Snack" at times when I normally wouldn't. Let us know how you are doing.
Posted by Ambrosia on May 27, 2001, at 23:46:00
In reply to Re: Tomamax for weight loss, posted by limey on May 27, 2001, at 8:32:31
Just a thought > > >I would recommend Topomax to anyone who wants to lose weight. In fact, I think they should market it for that purpose--it's got to be safer than taking dexadrine or other addictive drugs. I used to take it, and within 3 months I lost like 45 pounds without even trying. I simply wasn't hungry most of the time, and didn't have the drive to snack or overeat. > > >Ambrosia
Posted by limey on May 28, 2001, at 7:23:14
In reply to Re: Tomamax for weight loss, posted by Ambrosia on May 27, 2001, at 23:46:00
Thanks, just a few questions for you Ambrosia. What kind of side effects did you experience? When you went off Topamax did the weight return? My weight has crept up while I was on Paxil - until I am now at the point where I don't even weigh myself any more (too depressing!!!) Now, I am on effexor, I am hoping the Topamax added to it will help - because nothing I have done has helped!!!! Wish me luck! - limey
> Just a thought > > >I would recommend Topomax to anyone who wants to lose weight. In fact, I think they should market it for that purpose--it's got to be safer than taking dexadrine or other addictive drugs. I used to take it, and within 3 months I lost like 45 pounds without even trying. I simply wasn't hungry most of the time, and didn't have the drive to snack or overeat. > > >Ambrosia
Posted by Karla on May 30, 2001, at 10:30:38
In reply to Re: Topamax Experiences? » maribeth, posted by kathrynbabble on May 12, 2001, at 23:30:20
I have been on topamax for aprox a year now. My neuro told me you need to be on a dose of over 200mg or more to see weight loss results. I have been at 200mg. Haven't seen any loss but I have maintained my weight when I am on lithium and celexa and they should make me gain weight. So... hmmm. My neuro added my dosage up 25 mg every 2 weeks real slow. He said when people do it to fast they have problems. I found that every time I upped it I would experience tingling in my hands and feet. It would last for 2 or 3 days and then go away. I am currently taking lithium and topamax for prevention of cluster headaches. I have also found that topamax affect my memory. Can't remember nothing anymore. That is the biggest problem. Forget apts and I have them written in a calendar book. Forget where I am driven to. UG! It gets bad some days. Had to quit working. I am collecting disability now. The doctors thought it was the depression more than the meds messing with my mind but I disagree. Thats my
opinion.
Posted by Josie on May 30, 2001, at 17:50:55
In reply to Re: Topamax Experiences?, posted by Karla on May 30, 2001, at 10:30:38
Has anyone tried Neurontin? My son uses Neurontin for bipolar disorder and experiences little in the way of side effects and no weight issues.
Like many of you who have posted, he hated Topamax and had nasty symptoms with Wellbutrin.
Posted by KarenK on June 3, 2001, at 20:30:28
In reply to Re: Topamax Experiences?, posted by Karla on May 30, 2001, at 10:30:38
> I have been on topamax for aprox a year now. My neuro told me you need to be on a dose of over 200mg or more to see weight loss results. I have been at 200mg. Haven't seen any loss but I have maintained my weight when I am on lithium and celexa and they should make me gain weight. So... hmmm. My neuro added my dosage up 25 mg every 2 weeks real slow. He said when people do it to fast they have problems. I found that every time I upped it I would experience tingling in my hands and feet. It would last for 2 or 3 days and then go away. I am currently taking lithium and topamax for prevention of cluster headaches. I have also found that topamax affect my memory. Can't remember nothing anymore. That is the biggest problem. Forget apts and I have them written in a calendar book. Forget where I am driven to. UG! It gets bad some days. Had to quit working. I am collecting disability now. The doctors thought it was the depression more than the meds messing with my mind but I disagree. Thats my opinion.
It's the topamax that's affecting your memory. I had to start writing everything down too because I started forgetting appts. I started losing weight before 200mgs but the real effect came at 250mg. Of course by then I couldn't eat anything and then I had a whole new problem so I had to taper down.
Posted by mcmud on June 22, 2001, at 14:56:15
In reply to Re: Topamax Experiences?, posted by KarenK on June 3, 2001, at 20:30:28
I have been on 75 mg/day Topamax for phantom
pain (I'm an AK amp since '91) for about 6 mos. I started at 25 mg and worked up from there. It completely resolved one component of pain, but left others unaffected. I also take amitriptyline (75-100 mg),hydrocodone/acet.(10mg/650mg.- 4 tabs/day), and Celebrex (200 mg- 2 tabs/day). Together, they tone it down considerably, but do not completely stop it. When it gets going, it feels like my not-toe is stuck in a wall socket.To get back on topic, the Top. does make my arms and leg tingle noticeably and frequently. I also
notice that I awake frequently at night and think
that it is likely due to the Top. (it was not a
pattern before). I will probably switch to daytime dosing to nip that in the bud. I have noticed some irritability of late, but there are
other factors that I could attribute that to, so I
am monitoring it for the time being.
Posted by Kingfish on August 8, 2001, at 15:52:36
In reply to Re: Topamax Experiences: Long Term Use » maribeth, posted by Teddy Bishop on August 8, 2001, at 3:54:50
Maribeth:
I'm happy to see someone else has had a good experience with Topamax. I am currently at 250 mg and all side effects disappeared for me as well except for sedation, which most people don't seem to experience. I recently switched from Celexa to Prozac which kind of helped at first and am now adding Lamictal to see how its activating qualities help.
We'll see how that goes.
- K.
Posted by Lexie on August 8, 2001, at 21:25:36
In reply to Re: Topamax Experiences?, posted by Lexie on January 19, 2001, at 20:11:02
Hello All
Well, the recent post led me to get the E-Mail notifification that brought me back here yet once again. I have bad news. I am suffering. At 5'9" tall I am now 110 pounds and caught up in the most seductive fights for my life called "Anorexia", brought on I believe in part from the topamax. I got caught up at first in the "Appearance" part of it, wanted to look good again after all the weight I had gained on the AD's, now it is just a "CONTROL" issue, I can control everything that goes into my mouth. I can't control all of these crappy things going on around me but I can control the number on the scale. I don't have my ex-husband to control me so I will control this. My marriage was the "problem" and the "eating disorder" is the symptom to the problem. Everyone is pulling me every which direction and I feel like if I just don't eat "poof", I will just disintigrate! And then there will not be anything left for anyone. Keep in Touch everyone, Lexie (the one running from the feeding tube)
Posted by mcmud on August 9, 2001, at 11:20:33
In reply to Re: Topamax Experiences?, posted by Lexie on August 8, 2001, at 21:25:36
Hi everybody. Nothing too exciting here.
I had to back down to 50 mg/day because of
urinary stone formation. Wearing a prosthesis
in hot weather is a tremendous heat stress and
I am awash in sweat all day. Since the stone
episode, I have backed down, and drink a minimum
of 6 liters a day to make sure I stay hydrated.
I also drink cranberry juice to reduce the pH.
It was not my idea of a fun time. Incidentally,
my level of pain relief at 50 vs 75, does not seem to be significantly different. Again, I
I did notice some iritability, but could attribute it to a reaction to the heat stress.
Posted by bob on August 9, 2001, at 18:04:43
In reply to Re: Topamax Experiences re: nerve pain, posted by mcmud on August 9, 2001, at 11:20:33
> Hi everybody. Nothing too exciting here.
> I had to back down to 50 mg/day because of
> urinary stone formation. Wearing a prosthesis
> in hot weather is a tremendous heat stress and
> I am awash in sweat all day. Since the stone
> episode, I have backed down, and drink a minimum
> of 6 liters a day to make sure I stay hydrated.
> I also drink cranberry juice to reduce the pH.
> It was not my idea of a fun time. Incidentally,
> my level of pain relief at 50 vs 75, does not seem to be significantly different. Again, I
> I did notice some iritability, but could attribute it to a reaction to the heat stress.********************
I attained a 250mg level of Topomax, and got more and more irritable along the way. It was the medecine, without a doubt. At the end, I became aggressive and angry, while at other times despondent. I had to taper down some. Then I had a kidney stone attack. I spent 24 hours at the hospital passing a 4.5mm stone. When I was there, they found 3 more stones in that kidney, and another in the other kidney. They broke up the large stone in the kidney with 3, and luckily, the other two were jostled out with it, although not without significant pain. I am still carrying the other one since it is too small for ultrasound. It causes me pain sometimes. When my p-doc learned about my hospital visit, he ordered me to taper off the Topomax immediately and quickly, and completely. It was a VERY mentally destabilizing odyssey of terror and pain. For some reason, I was extremely sensitive to Topomax, and especially to dose level changes. I guess you could say it wasn't for me.
Bob
Posted by Mitch on August 9, 2001, at 23:42:46
In reply to Re: Topamax Experiences re: nerve pain, posted by bob on August 9, 2001, at 18:04:43
> > Hi everybody. Nothing too exciting here.
> > I had to back down to 50 mg/day because of
> > urinary stone formation. Wearing a prosthesis
> > in hot weather is a tremendous heat stress and
> > I am awash in sweat all day. Since the stone
> > episode, I have backed down, and drink a minimum
> > of 6 liters a day to make sure I stay hydrated.
> > I also drink cranberry juice to reduce the pH.
> > It was not my idea of a fun time. Incidentally,
> > my level of pain relief at 50 vs 75, does not seem to be significantly different. Again, I
> > I did notice some iritability, but could attribute it to a reaction to the heat stress.
>
> ********************
>
> I attained a 250mg level of Topomax, and got more and more irritable along the way. It was the medecine, without a doubt. At the end, I became aggressive and angry, while at other times despondent. I had to taper down some. Then I had a kidney stone attack. I spent 24 hours at the hospital passing a 4.5mm stone. When I was there, they found 3 more stones in that kidney, and another in the other kidney. They broke up the large stone in the kidney with 3, and luckily, the other two were jostled out with it, although not without significant pain. I am still carrying the other one since it is too small for ultrasound. It causes me pain sometimes. When my p-doc learned about my hospital visit, he ordered me to taper off the Topomax immediately and quickly, and completely. It was a VERY mentally destabilizing odyssey of terror and pain. For some reason, I was extremely sensitive to Topomax, and especially to dose level changes. I guess you could say it wasn't for me.
>
> BobBob, et al,
Tegretol and Trileptal have carbonic anyhydrase inhibitor activity which can also result in kidney stones as well. If anyone is sensitive to this problem they should also avoid these two meds as a result from a switch from Topamax.
Mitch
Posted by Mitch on August 9, 2001, at 23:45:17
In reply to Re: Topamax Experiences re: nerve pain, posted by bob on August 9, 2001, at 18:04:43
> > Hi everybody. Nothing too exciting here.
> > I had to back down to 50 mg/day because of
> > urinary stone formation. Wearing a prosthesis
> > in hot weather is a tremendous heat stress and
> > I am awash in sweat all day. Since the stone
> > episode, I have backed down, and drink a minimum
> > of 6 liters a day to make sure I stay hydrated.
> > I also drink cranberry juice to reduce the pH.
> > It was not my idea of a fun time. Incidentally,
> > my level of pain relief at 50 vs 75, does not seem to be significantly different. Again, I
> > I did notice some iritability, but could attribute it to a reaction to the heat stress.
>
> ********************
>
> I attained a 250mg level of Topomax, and got more and more irritable along the way. It was the medecine, without a doubt. At the end, I became aggressive and angry, while at other times despondent. I had to taper down some. Then I had a kidney stone attack. I spent 24 hours at the hospital passing a 4.5mm stone. When I was there, they found 3 more stones in that kidney, and another in the other kidney. They broke up the large stone in the kidney with 3, and luckily, the other two were jostled out with it, although not without significant pain. I am still carrying the other one since it is too small for ultrasound. It causes me pain sometimes. When my p-doc learned about my hospital visit, he ordered me to taper off the Topomax immediately and quickly, and completely. It was a VERY mentally destabilizing odyssey of terror and pain. For some reason, I was extremely sensitive to Topomax, and especially to dose level changes. I guess you could say it wasn't for me.
>
> BobBob, et al,
Tegretol and Trileptal have carbonic anyhydrase inhibitor activity which can also result in kidney stones as well. If anyone is sensitive to this problem they should also avoid these two meds as a result from a switch from Topamax.
Mitch
Posted by bob on August 10, 2001, at 23:28:25
In reply to Re: Topamax Experiences re: nerve pain » bob, posted by Mitch on August 9, 2001, at 23:45:17
> > > Hi everybody. Nothing too exciting here.
> > > I had to back down to 50 mg/day because of
> > > urinary stone formation. Wearing a prosthesis
> > > in hot weather is a tremendous heat stress and
> > > I am awash in sweat all day. Since the stone
> > > episode, I have backed down, and drink a minimum
> > > of 6 liters a day to make sure I stay hydrated.
> > > I also drink cranberry juice to reduce the pH.
> > > It was not my idea of a fun time. Incidentally,
> > > my level of pain relief at 50 vs 75, does not seem to be significantly different. Again, I
> > > I did notice some iritability, but could attribute it to a reaction to the heat stress.
> >
> > ********************
> >
> > I attained a 250mg level of Topomax, and got more and more irritable along the way. It was the medecine, without a doubt. At the end, I became aggressive and angry, while at other times despondent. I had to taper down some. Then I had a kidney stone attack. I spent 24 hours at the hospital passing a 4.5mm stone. When I was there, they found 3 more stones in that kidney, and another in the other kidney. They broke up the large stone in the kidney with 3, and luckily, the other two were jostled out with it, although not without significant pain. I am still carrying the other one since it is too small for ultrasound. It causes me pain sometimes. When my p-doc learned about my hospital visit, he ordered me to taper off the Topomax immediately and quickly, and completely. It was a VERY mentally destabilizing odyssey of terror and pain. For some reason, I was extremely sensitive to Topomax, and especially to dose level changes. I guess you could say it wasn't for me.
> >
> > Bob
>
> Bob, et al,
>
> Tegretol and Trileptal have carbonic anyhydrase inhibitor activity which can also result in kidney stones as well. If anyone is sensitive to this problem they should also avoid these two meds as a result from a switch from Topamax.
>
> MitchThank you for the info Mitch!
Bob
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